Evading Growth Suppression: TGFB Signaling

This lecture covers the mechanisms by which cells evade growth suppression, focusing on the role of Transforming Growth Factor Beta (TGFB) signaling. Topics include the impact of NF1, PTEN, and Smad4 mutations on growth regulation, the essential functions of PTEN and p53 in cancer prevention, and the intricate intracellular signaling pathways involving Cyclin D, Mdm2, and p53. The lecture also discusses the genetic origin of cancer, the role of tumor suppressors and oncogenes, and the therapeutic strategies to restore p53 activity. Various mouse models and experimental data are presented to illustrate the tumor suppressive functions of TGFB signaling in different tissues.