Concept

Germ cell tumor

Related publications (188)

Cell lineage tracing in human tissues using somatic mitochondrial mutations

Lineage tracing is a basic concept in developmental biology, as well as diseases related to organ development. A reliable method to track cell lineages in human tissues has the potential to greatly contribute to the fields of oncogenesis, tissue renewal, a ...

EPFL2017

Mapping mitochondrial heteroplasmy in a Leydig tumor by laser capture microdissection and cycling temperature capillary electrophoresis

Stephan Morgenthaler, Paul Refinetti, Per Olaf Ekstrom

Background: The growth of tumor cells is accompanied by mutations in nuclear and mitochondrial genomes creating marked genetic heterogeneity. Tumors also contain non-tumor cells of various origins. An observed somatic mitochondrial mutation would have occu ...

BioMed Central2017

Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma

Paolo Angelino, Etienne Meylan, Mauro Delorenzi, Jessica Christine Vazquez, Pierre-Benoit Bernard Ancey, Stefania Crippa, Olivier Michielin

Hepatoblastoma is the most common malignant pediatric liver cancer. Histological evaluation of tumor biopsies is used to distinguish among the different subtypes of hepatoblastoma, with fetal and embryonal representing the two main epithelial components. W ...

2017

Iron oxide nanoparticles for diagnosis and therapy of lymph node metastases

Débora Bonvin

This thesis presents the synthesis, coating and characterization of iron oxide nanoparticles (IONPs) with properties especially designed for the ultimate simultaneous MRI detection and hyperthermia treatment of lymph node metastases, a combination called t ...

EPFL2017

Precision targeting of tumor macrophages with a CD206 binding peptide

Michele De Palma, Mario Leonardo Squadrito

Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse. Here, we describe a peptide that selectively targets MRC1-express ...

2017

ATP and NADPH coated iron oxide nanoparticles for targeting of highly metabolic tumor cells

Dominique Bonvin, Heinrich Hofmann

The metabolic activity of tumor cells is known to be higher as compared to that of normal cells, which has been previously exploited to deliver nanomedicines to highly metabolic tumor cells. Unfortunately, current strategies, which are mostly based on comp ...

Royal Soc Chemistry2017

Single Cell Electrochemiluminescence Imaging: From the Proof-of-Concept to Disposable Device-Based Analysis

Andreas Stephan Lesch, Milica Jovic

We report here the development of coreactant-based electro-generated chemiluminescence (ECL) as a surface-confined microscopy to image single cells and their membrane proteins. Labeling the entire cell membrane allows one to demonstrate that, by contrast w ...

American Chemical Society2017

RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation

Nadine Fournier, Paolo Angelino, Etienne Meylan, Mauro Delorenzi, Alessandra Piersigilli, Jawahar Kopparam, Johanna Pauline Chiffelle

Loss of epithelial differentiation and extracellular matrix (ECM) remodeling are known to facilitate cancer progression and are associated with poor prognosis in patients with lung cancer. We have identified Receptor-interacting serine/threonine protein ki ...

Nature Publishing Group2017

Angiopoietin-1 deficiency increases tumor metastasis in mice

Iacovos Michael

Background: Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts permeability induced by a number of ...

2017

Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Ume-Gulsoom Abdul, Marije Trudi Te Winkel

Cancer cells are often dependent on epigenetic pathways for their survival. Consequently, drugs that target the epigenome, rather than the underlying DNA sequence, are currently attracting considerable attention. In recent years, the first epigenetic drugs ...

Springer Verlag2017

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