Publications related to Genome-wide association study

The ultimate and proximate mechanisms driving the evolution of long tails in forest deer mice

Understanding both the role of selection in driving phenotypic change and its underlying genetic basis remain major challenges in evolutionary biology. Here, we use modern tools to revisit a classic system of local adaptation in the North American deer mou ...

Wiley2017

Combining genotype, phenotype and environment to infer potential candidate genes: An example using the Loblolly pine (Pinus taeda)

Stéphane Joost

Population genomic analyses can be an important tool in understanding local adaptation. Identification of potential adaptive loci in such analyses is usually based on the survey of a large genomic dataset in combination with environmental variables. Phenot ...

Oxford University Press2017

The genomic landscape of human cellular circadian variation points to a novel role for the signalosome

Frédéric Bruno Martin Gachon, Konstantin Popadin, Daniel Alain Dominique Marie Mauvoisin

The importance of natural gene expression variation for human behavior is undisputed, but its impact on circadian physiology remains mostly unexplored. Using umbilical cord fibroblasts, we have determined by genome-wide association how common genetic varia ...

Elife Sciences Publications Ltd2017

Structure and dynamics of mesophilic variants from the homing endonuclease I-DmoI

I-DmoI, from the hyperthermophilic archaeon Desulfurococcus mobilis, belongs to the LAGLIDADG homing endonuclease protein family. Its members are highly specific enzymes capable of recognizing long DNA target sequences, thus providing potential tools for g ...

Springer2017

MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering

Christian Iseli, Nicolas Mermod, Thomas Junier, Samuel Neuenschwander, Ioannis Xenarios

Untargeted plasmid integration into mammalian cell genomes remains a poorly understood and inefficient process. The formation of plasmid concatemers and their genomic integration has been ascribed either to non-homologous end-joining (NHEJ) or homologous r ...

2017

The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution

Jeffrey David Jensen, Claudia Bank, Sebastian Matuszewski, Nicky Louise Ormond

Influenza virus inflicts a heavy death toll annually and resistance to existing antiviral drugs has generated interest in the development of agents with novel mechanisms of action. Favipiravir is an antiviral drug that acts by increasing the genome-wide mu ...

Oxford University Press (OUP)2017

Whole genome sequencing distinguishes between relapse and reinfection in recurrent leprosy cases

Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Pushpendra Singh, Jérémie Piton, Chloé Marie Loiseau

Background Since leprosy is both treated and controlled by multidrug therapy (MDT) it is important to monitor recurrent cases for drug resistance and to distinguish between relapse and reinfection as a means of assessing therapeutic efficacy. All three obj ...

Public Library Science2017

Persistence of butterfly populations in fragmented habitats along urban density gradients: motility helps

Stéphane Joost, Estelle Rochat, Ivo Widmer

In a simulation study of genotypes conducted over 100 generations for more than 1600 butterfly’s individuals, we evaluate how the increase of anthropogenic fragmentation and reduction of habitat size along urbanisation gradients (from 7% to 59% of impervio ...

Nature Publishing Group2017

Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World

Felix Naef, Jake Yeung, Jérôme Mermet

Mammals have evolved an internal timing system, the circadian clock, which synchronizes physiology and behavior to the daily light and dark cycles of the Earth. The master clock, located in the suprachiasmatic nucleus (SCN) of the brain, takes fluctuating ...

Cold Spring Harbor Lab Press, Publications Dept2017

Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World

Felix Naef, Jake Yeung, Jérôme Mermet

Mammals have evolved an internal timing system, the circadian clock, which synchronizes physiology and behavior to the daily light and dark cycles of the Earth. The master clock, located in the suprachiasmatic nucleus (SCN) of the brain, takes fluctuating ...

Cold Spring Harbor Lab Press, Publications Dept2017

Genome-wide association study

The ultimate and proximate mechanisms driving the evolution of long tails in forest deer mice

Combining genotype, phenotype and environment to infer potential candidate genes: An example using the Loblolly pine (Pinus taeda)

The genomic landscape of human cellular circadian variation points to a novel role for the signalosome

Structure and dynamics of mesophilic variants from the homing endonuclease I-DmoI

MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering

The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution

Whole genome sequencing distinguishes between relapse and reinfection in recurrent leprosy cases

Persistence of butterfly populations in fragmented habitats along urban density gradients: motility helps

Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World

Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World

Graph Chatbot

Chat with Graph Search

The genomic landscape of human cellular circadian variation points to a novel role for the signalosome

The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution

Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World

Structure and dynamics of mesophilic variants from the homing endonuclease I-DmoI

Combining genotype, phenotype and environment to infer potential candidate genes: An example using the Loblolly pine (Pinus taeda)

The ultimate and proximate mechanisms driving the evolution of long tails in forest deer mice

Whole genome sequencing distinguishes between relapse and reinfection in recurrent leprosy cases

MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering

Persistence of butterfly populations in fragmented habitats along urban density gradients: motility helps

Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World