Concept
Enterovirus
Related publications (32)
Influence of Amino Acid Substitutions in Capsid Proteins of Coxsackievirus B5 on Free Chlorine and Thermal Inactivation
Tamar Kohn, Aleksandar Antanasijevic, Kiruthika Kumar, Shotaro Torii
The sensitivity of enteroviruses to disinfectants varies among genetically similar variants and coincides with amino acid changes in capsid proteins, although the effect of individual substitutions remains unknown. Here, we employed reverse genetics to inv ...
2024Observed Kinetics of Enterovirus Inactivation by Free Chlorine Are Host Cell-Dependent
Tamar Kohn, Shannon Christa David, Shotaro Torii, Federica Cariti
Virucidal efficacies of disinfectants are typically assessed by infectivity assay utilizing a single type of host cell. Enteroviruses infect multiple host cells via various entry routes, and each entry route may be impaired differently by a given disinfect ...
2023Selective elimination of enterovirus genotypes by activated sludge and chlorination
Enteroviruses, which are commonly circulating viruses shed in the stool, are released into the sewage system and only partially removed or inactivated, resulting in the discharge of infectious enteroviruses into the environment. Activated sludge and chlori ...
2023Numerical simulation of the fate, transport and public health risks of enteric viruses in Lake Geneva
Lakes are a fundamental feature of nature with brilliance, profoundness and complexity. Various of physical, chemical and biological changes take place three dimensionally in deep lakes, regulated by complicated boundary conditions. To understand and predi ...
EPFL2023Genotype-Dependent Kinetics of Enterovirus Inactivation by Free Chlorine and Ultraviolet (UV) Irradiation
Inactivation kinetics of enterovirus by disinfection is often studied using a single laboratory strain of a given genotype. Environmental variants of enterovirus are genetically distinct from the corresponding laboratory strain, yet it is poorly understood ...
2022Effect of wastewater treatment and environmental exposure on an enterovirus population
Odile Marie Clotilde Hervás de Nalda-Larivé
The presence of viruses in recreational water can present a risk for human health and wastewater effluent is a source of virus in the environment. Their persistence in the environment influences their probability to find a new host. Studies have shown that ...
EPFL2022An integrated cell culture reverse transcriptase quantitative PCR (ICC-RTqPCR) method to simultaneously quantify the infectious concentrations of eight environmentally relevant enterovirus serotypes
Tamar Kohn, Jade Brandani, Manupriyam Dubey
Enterovirus (EV) infectivity is typically measured as a bulk parameter, yet EV serotypes vary in their susceptibility to natural and engineered stressors. Here we developed an integrated cell culture reverse transcriptase quantitative PCR (ICC-RTqPCR) meth ...
2021Salt enhances the thermostability of enteroviruses by stabilizing capsid protein interfaces
Tamar Kohn, Matteo Dal Peraro, Simon Meister, Alessio Prunotto
Enteroviruses are common agents of infectious disease that are spread by the fecal-oral route. They are readily inactivated by mild heat, which causes the viral capsid to disintegrate or undergo conformational change. While beneficial for the thermal treat ...
2020Adaptation of Human Enterovirus to Warm Environments Leads to Resistance against Chlorine Disinfection
Tamar Kohn, Anna Carratala Ripolles, Virginie Bachmann, Timothy R. Julian
Sunlight, temperature, and microbial grazing are among the environmental factors promoting the inactivation of viral pathogens in surface waters. Globally, these factors vary across time and space. The persistence of viral pathogens, and ultimately their e ...
2020Unveiling Viruses Associated with Gastroenteritis Using a Metagenomics Approach
Acute infectious gastroenteritis is an important illness worldwide, especially on children, with viruses accounting for approximately 70% of the acute cases. A high number of these cases have an unknown etiological agent and the rise of next generation seq ...
MDPI2020