Concept
Phosphatidylinositol
Related publications (34)
Membrane specificity of the human cholesterol transfer protein STARD4
Charlotte Julie Caroline Gehin
STARD4 regulates cholesterol homeostasis by transferring cholesterol between the plasma membrane and endoplasmic reticulum. The STARD4 structure features a helix-grip fold surrounding a large hydrophobic cavity holding the sterol. Its access is controlled ...
Academic Press Ltd- Elsevier Science Ltd2024Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial
PURPOSE The PNOC001 phase II single-arm trial sought to estimate progression-free survival (PFS) associated with everolimus therapy for progressive/recurrent pediatric low-grade glioma (pLGG) on the basis of phosphatidylinositol 3-kinase (PI3K)/AKT/mammali ...
2023S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami
Efficient immune responses require Ca2+ fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 channel a ...
eLIFE SCIENCES PUBL LTD2021Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholi ...
Springer2019Probing the distribution of cortical components, including PtdIns(4,5)P2, during asymmetric division of C. elegans embryos
Asymmetric cell division is crucial for embryonic development and stem cell lineages. In the one-cell C. elegans embryo, a contractile cortical actomyosin network contributes to asymmetric division by segregating PAR proteins to discrete cortical domains. ...
EPFL2018A Click Cage: Organelle‐Specific Uncaging of Lipid Messengers
Lipid messengers exert their function on short time scales at distinct subcellular locations, yet most experimental approaches for perturbing their levels trigger cell-wide concentration changes. Herein, we report on a coumarin-based photocaging group that ...
2018Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase
Florence Pojer, Sandrine Madeleine Suzanne Georgeon, Charlotte Julie Caroline Gehin, Oliver Hantschel, Sina Maren Reckel, Tim Kükenshöner, Delphine Maude Tardivon, Barbara Gerig, Sara Raquel Pereira Pinho
The two isoforms of the Bcr-Abl tyrosine kinase, p210 and p190, are associated with different leukemias and have a dramatically different signaling network, despite similar kinase activity. To provide a molecular rationale for these observations, we study ...
Springer Nature2017Interfacial Structure and Hydration of 3D Lipid Monolayers in Aqueous Solution
Sylvie Roke, Nikolay Smolentsev, Yixing Chen, Halil Ibrahim Okur, Evangelia Zdrali
Three-dimensional (3D) phospholipid monolayers at hydrophobic surfaces are ubiquitous and found in nature as adiposome organelles or in man-made materials such as drug delivery systems. However, the molecular level understanding of such monolayers remains ...
American Chemical Society2017Towards a kinetic model of the phospholipids biosynthesis of the yeast Saccharomyces cerevisiae
Vassily Hatzimanikatis, Meriç Ataman, Georgios Savoglidis, Iro Oikonomidi
Lipids, as vital eukaryotic cellular components, play a major role in cell, tissue and organ physiology. Alterations of lipid enzymes and metabolic pathways are related to many human diseases, such as cancer, diabetes and neurodegenerative diseases. In thi ...
2014Phosphatidylinositol-4-phosphate: The Golgi and beyond
Initially identified as a key phosphoinositide that controls membrane trafficking at the Golgi complex, phosphatidylinositol-4-phosphate (PI4P) has emerged as a key molecule in the regulation of a diverse array of cellular functions. In this review we will ...
2013