Concept

Astrogliosis

Related publications (102)

Calcium Dynamics and Intercellular Communication in Arterial Smooth Muscle Cells in Vitro

Tissue blood flow is controlled by changes in the diameter of the arteries and arterioles through coordinated contraction and relaxation of smooth muscle cells (SMCs) within the vascular wall. The contraction of SMCs is primarily regulated by the intracell ...

EPFL2011

Comment on recent modeling studies of astrocyte-neuron metabolic interactions

Pierre Magistretti, Igor Allaman, Renaud Jolivet, Luc Pellerin

Recent years have seen a surge in mathematical modeling of the various aspects of neuron-astrocyte interactions, and the field of brain energy metabolism is no exception in that regard. Despite the advent of biophysical models in the field, the long-lastin ...

Nature Publishing Group2010

Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability

Pierre Magistretti, Hilal Lashuel, Igor Allaman, Thierry Laroche, David Viertl

Amyloid-beta (Abeta) peptides play a key role in the pathogenesis of Alzheimer's disease and exert various toxic effects on neurons; however, relatively little is known about their influence on glial cells. Astrocytes play a pivotal role in brain homeostas ...

2010

Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury

Grégoire Courtine, Michael Aaron Miller

Although axonal regeneration after CNS injury is limited, partial injury is frequently accompanied by extensive functional recovery. To investigate mechanisms underlying spontaneous recovery after incomplete spinal cord injury, we administered C7 spinal co ...

2010

Glycogen metabolism as a marker of astrocyte differentiation

Pierre Magistretti, Igor Allaman, Luc Pellerin

Glycogen is a hallmark of mature astrocytes, but its emergence during astrocytic differentiation is unclear. Differentiation of E14 mouse neurospheres into astrocytes was induced with fetal bovine serum (FBS), Leukemia Inhibitory Factor (LIF), or Ciliary N ...

2009

Glial Glycogen Metabolism

Igor Allaman

Glycogen represents the largest energy reserve of the brain and is almost quite exclusively localized in astrocytes. In the first part of this article, a summary of our knowledge concerning brain glycogen metabolism and its regulation is presented. The sec ...

Academic Press2009

Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells

CNS regeneration is limited by lesion-induced neuronal apoptosis and an environment inhibiting axonal elongation. Inhibition of ROCK has been previously shown to promote regeneration in retinal ganglion cells (RGC) whereas Cdk5 inhibition mainly promoted s ...

2009

Glial Energy Metabolism: A NMR Spectroscopy Perspective

Rolf Gruetter

Oxygen metabolism is uniquely compartmentalized between neurons and glia, the latter comprising about 25% of neuronal energy metabolism. The consumption of acetate and fixation of CO2 in glutamine occur in astrocytes by oxygen-dependent reactions, which po ...

Elsevier2009

Ni-Catalyzed Sonogashira Coupling of Non-activated Alkyl Halides: Orthogonal Functionalization of Alkyl Iodides, Bromides, and Chlorides

Xile Hu, Oleg Vechorkin, Valérie Proust, Delphine Barmaz

Ni-catalyzed Sonogashira coupling of nonactivated, β-H- containing alkyl halides, including chlorides, is reported. The coupling is tolerant to a wide range of functional groups, including ether, ester, amide, nitrile, keto, heterocycle, acetal, and aryl h ...

2009

Modulation of astrocytic metabolic phenotype by proinflammatory cytokines

Pierre Magistretti, Igor Allaman

Astrocytes play an important role in nervous system homeostasis. In particular, they contribute to the regulation of local energy metabolism and to oxidative stress defence. In previous experiments, we showed that long-term treatment with interleukin 1alph ...

2008

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.