Publications related to Neuromyelitis optica spectrum disorder

Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function

Gioele La Manno, Zahra Moslehi, Nina-Lydia Kazakou

The myelinated white matter tracts of the central nervous system (CNS) are essential for fast transmission of electrical impulses and are often differentially affected in human neurodegenerative diseases across CNS region, age and sex. We hypothesize that ...

BMC2023

Cortical lesions, central vein sign, and paramagnetic rim lesions in multiple sclerosis: Emerging machine learning techniques and future avenues

Jean-Philippe Thiran, Meritxell Bach Cuadra, Tobias Kober, Cristina Granziera, Francesco La Rosa, Maxence Charles F Wynen

The current diagnostic criteria for multiple sclerosis (MS) lack specificity, and this may lead to misdiagnosis, which remains an issue in present-day clinical practice. In addition, conventional biomarkers only moderately correlate with MS disease progres ...

ELSEVIER SCI LTD2022

CVSnet: A machine learning approach for automated central vein sign assessment in multiple sclerosis

Meritxell Bach Cuadra, Tobias Kober, Reto Meuli, Cristina Granziera, Jonas Richiardi, João Pedro Forjaco Jorge, Mario Joao Fartaria de Oliveira, Francesco La Rosa

The central vein sign (CVS) is an efficient imaging biomarker for multiple sclerosis (MS) diagnosis, but its application in clinical routine is limited by inter-rater variability and the expenditure of time associated with manual assessment. We describe a ...

2020

Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity

Tobias Kober, Bénédicte Marie Maréchal, Mario Joao Fartaria de Oliveira

Neurofilament light chain (NfL) has been demonstrated to correlate with multiple sclerosis disease severity as well as treatment response. Nevertheless, additional serum biomarkers are still needed to better differentiate disease activity from disease prog ...

2020

RimNet: A deep 3D multimodal MRI architecture for paramagnetic rim lesion assessment in multiple sclerosis

Meritxell Bach Cuadra, Tobias Kober, Cristina Granziera, Francesco La Rosa, Hamza Kebiri, Po-Jui Lu

Objectives In multiple sclerosis (MS), the presence of a paramagnetic rim at the edge of non-gadolinium-enhancing lesions indicates perilesional chronic inflammation. Patients featuring a higher paramagnetic rim lesion burden tend to have more aggressive d ...

2020

Robust myelin water imaging from multi-echo T2 data using second-order Tikhonov regularization with control points

Jean-Philippe Thiran, Tobias Kober, Tom Hilbert, Erick Jorge Canales Rodriguez, Marco Pizzolato, Gian Franco Piredda, Alessandro Daducci, Nicolas Kunz

Myelin water imaging is an MRI technique used to quantify myelination in the brain. The state-of-the-art reconstruction method is based on non-negative least squares optimization with zero-order Tikhonov regularization. In this study, a second-order Tikhon ...

2019

Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice

Maurizio Molinari, Francesca Bianchi

In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral nerve myelin. In humans, mutations in P0 cause the demyelinating Charcot-Marie-Tooth 1B ...

2019

An Ultra-High Field Study of Cerebellar Pathology in Early Relapsing-Remitting Multiple Sclerosis Using MP2RAGE

Meritxell Bach Cuadra, Tobias Kober, Cristina Granziera, Alexis Roche, Guillaume Bonnier, Mario Joao Fartaria de Oliveira, Kieran O'Brien, Pavel Falkovskiy

Objectives: The aim of this study was to study focal cerebellar pathology in early stages of multiple sclerosis (MS) using ultra-high-field magnetization-prepared 2 inversion-contrast rapid gradient-echo (7T MP2RAGE). Materials and Methods: Twenty early-st ...

Lippincott, Williams & Wilkins2017

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