The Fore (ˈfɔːreɪ) people live in the Okapa District of the Eastern Highlands Province, Papua New Guinea. There are approximately 20,000 Fore who are separated by the Wanevinti Mountains into the North Fore and South Fore regions. Their main form of subsistence is slash-and-burn farming. The Fore language has three distinct dialects and is the southernmost member of the East Central Family, East New Guinea Highlands Stock, Trans–New Guinea phylum of Papuan languages.
In the 1950s the neurological disease kuru was discovered in the South Fore. The local tradition of ritual cannibalism of their dead had led to an epidemic, with approximately 1,000 deaths from 1957 to 1960.
Until the 1950s, the Fore people had minimal direct contact with outsiders who were at the time colonizing Papua New Guinea. A small number of prospectors crossed through their territory in the 1930s and at least one plane crashed there during World War II. New diseases such as influenza reached them before significant contact with colonial people occurred.
In the late 1940s, colonial government patrols reached further and further into Fore territory. The patrol officers, called kiaps by the Fore, tried to conduct a census in each village they passed through and lectured the villagers on the importance of hygiene and road construction. They encouraged the people to give up village warfare, traditional beliefs and cannibalism as well. These officers attempted to recruit local 'big men' to represent the colonial authorities as headmen (luluais) or as deputies (tultuls).
In 1951, a police post was set up at Okapa (then known as Moke) among the North Fore. A patrol officer, John R. McArthur, was stationed there from 1954 when the "rough track" from Kainantu opened to traffic. Transportation in the region improved to such a degree that it was possible to drive a Land Rover or motorbike to Purosa among the South Fore by 1957. At this time, colonial authorities estimated that there were at least 12,000 Fore living in the region.
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Kuru is a rare, incurable, and fatal neurodegenerative disorder that was formerly common among the Fore people of Papua New Guinea. Kuru is a form of transmissible spongiform encephalopathy (TSE) caused by the transmission of abnormally folded proteins (prions), which leads to symptoms such as tremors and loss of coordination from neurodegeneration. The term kuru derives from the Fore word kuria or guria ("to shake"), due to the body tremors that are a classic symptom of the disease. Kúru itself means "trembling".
Cannibalism is the act of consuming another individual of the same species as food. Cannibalism is a common ecological interaction in the animal kingdom and has been recorded in more than 1,500 species. Human cannibalism is well documented, both in ancient and in recent times. The rate of cannibalism increases in nutritionally poor environments as individuals turn to members of their own species as an additional food source.
Human cannibalism is the act or practice of humans eating the flesh or internal organs of other human beings. A person who practices cannibalism is called a cannibal. The meaning of "cannibalism" has been extended into zoology to describe an individual of a species consuming all or part of another individual of the same species as food, including sexual cannibalism. Neanderthals are believed to have practised cannibalism, and Neanderthals may have been eaten by anatomically modern humans.
Mice devoid of functional PrP genes (Prn-p(0/0) mice) showed normal development and behaviour. When inoculated with mouse scrapie prions they remained free of scrapie symptoms for at least 18 months whereas wild-type controls all died within 6 months. No p ...
1994
S.B. Prusiner proposed that the infectious agent of scraple, the prion, is PrPSc, a modified form of the normal host protein PrPC. Prn-p0/0 mice devoid of PrPC showed normal development and behavior. When inoculated with mouse scrapie prions, they remained ...
Prusiner proposed that the infectious agent of scrapie, the prion, is PrPSc, a modified form of the normal host protein PrPC. Prn-p0/0 mice devoid of PrPC showed normal development and behavior. When inoculated with mouse scrapie prions they remained free ...