The Fore (ˈfɔːreɪ) people live in the Okapa District of the Eastern Highlands Province, Papua New Guinea. There are approximately 20,000 Fore who are separated by the Wanevinti Mountains into the North Fore and South Fore regions. Their main form of subsistence is slash-and-burn farming. The Fore language has three distinct dialects and is the southernmost member of the East Central Family, East New Guinea Highlands Stock, Trans–New Guinea phylum of Papuan languages.
In the 1950s the neurological disease kuru was discovered in the South Fore. The local tradition of ritual cannibalism of their dead had led to an epidemic, with approximately 1,000 deaths from 1957 to 1960.
Until the 1950s, the Fore people had minimal direct contact with outsiders who were at the time colonizing Papua New Guinea. A small number of prospectors crossed through their territory in the 1930s and at least one plane crashed there during World War II. New diseases such as influenza reached them before significant contact with colonial people occurred.
In the late 1940s, colonial government patrols reached further and further into Fore territory. The patrol officers, called kiaps by the Fore, tried to conduct a census in each village they passed through and lectured the villagers on the importance of hygiene and road construction. They encouraged the people to give up village warfare, traditional beliefs and cannibalism as well. These officers attempted to recruit local 'big men' to represent the colonial authorities as headmen (luluais) or as deputies (tultuls).
In 1951, a police post was set up at Okapa (then known as Moke) among the North Fore. A patrol officer, John R. McArthur, was stationed there from 1954 when the "rough track" from Kainantu opened to traffic. Transportation in the region improved to such a degree that it was possible to drive a Land Rover or motorbike to Purosa among the South Fore by 1957. At this time, colonial authorities estimated that there were at least 12,000 Fore living in the region.
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Le kuru est une maladie à prions (comme la maladie de la vache folle), découverte en Nouvelle-Guinée au début du . La maladie du kuru a été décrite chez le peuple des Fore de Nouvelle-Guinée par et D. Carleton Gajdusek (prix Nobel de médecine 1976), ainsi que d'autres chercheurs. Quoique distinct de la maladie de Creutzfeldt-Jakob, le kuru est également une encéphalopathie spongiforme transmissible. Son mode de transmission a pu être relié à un rite funéraire anthropophage. Le mot kuru signifie « trembler de peur », en fore.
vignette|Cannibalisme au Brésil en 1557 décrit par Hans Staden. vignette|Exemple de comportement de cannibalisme occasionnellement observé chez certaines larves de coccinelle Harmonia axyridis manquant de nourriture ou présentes en densité inhabituelle. Le cannibalisme est une pratique qui consiste à consommer, complètement ou partiellement, un individu de sa propre espèce. L'expression s'applique à la fois aux animaux qui dévorent des membres de leur groupe, cannibalisme animal, et aux êtres humains qui consomment de la chair humaine, cannibalisme et/ou anthropophagie.
vignette|300px|Scène de cannibalisme au Brésil au . Gravure tirée du livre de Hans Staden Nus, féroces et anthropophages, 1557. L’anthropophagie (du grec , « être humain », et qui se rapporte à l'action de « consommer ») est une pratique qui consiste à se nourrir d'êtres humains. L'anthropophagie peut recouvrir des réalités profondément différentes selon la civilisation, la période historique et les individus. Elle a dans beaucoup de sociétés une fonction rituelle ou magique.
Mice devoid of functional PrP genes (Prn-p(0/0) mice) showed normal development and behaviour. When inoculated with mouse scrapie prions they remained free of scrapie symptoms for at least 18 months whereas wild-type controls all died within 6 months. No p ...
1994
S.B. Prusiner proposed that the infectious agent of scraple, the prion, is PrPSc, a modified form of the normal host protein PrPC. Prn-p0/0 mice devoid of PrPC showed normal development and behavior. When inoculated with mouse scrapie prions, they remained ...
Prusiner proposed that the infectious agent of scrapie, the prion, is PrPSc, a modified form of the normal host protein PrPC. Prn-p0/0 mice devoid of PrPC showed normal development and behavior. When inoculated with mouse scrapie prions they remained free ...