Concept
Chromosomal inversion
Related publications (40)
The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase(+) cells and telomeric recombination in ALT(+) cells
Joachim Lingner, Rita Valador Fernandes
Telomeres are the nucleoprotein structures at the ends of linear chromosomes. Telomeres are transcribed into long non-coding Telomeric Repeat-Containing RNA (TERRA), whose functions rely on its ability to associate with telomeric chromatin. The conserved T ...
OXFORD UNIV PRESS2023Functional analysis of the telomeric long non-coding RNA TERRA
Telomeres are nucleoprotein structures present in the end of linear chromosomes. In humans, a core complex of 6 proteins cap and protect the chromosome ends from being recognized as double-strand breaks and eliciting unwanted DNA damage and repair response ...
EPFL2019Expression and differential regulation of human TERRA at several chromosome ends
Joachim Lingner, Marianna Feretzaki, Patricia Renck Nunes
The telomeric long noncoding RNA TERRA has been implicated in regulating telomere maintenance by telomerase and homologous recombination, and in influencing telomeric protein composition during the cell cycle and the telomeric DNA damage response. TERRA tr ...
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2019Gender medicine and oncology: report and consensus of an ESMO workshop
Background: The importance of sex and gender as modulators of disease biology and treatment outcomes is well known in other disciplines of medicine, such as cardiology, but remains an undervalued issue in oncology. Considering the increasing evidence for t ...
OXFORD UNIV PRESS2019Infrared nanospectroscopic mapping of a single metaphase chromosome
Giovanni Dietler, Andrzej Kulik, Francesco Simone Ruggeri, Ewelina Wioletta Lipiec
The integrity of the chromatin structure is essential to every process occurring within eukaryotic nuclei. However, there are no reliable tools to decipher the molecular composition of metaphase chromosomes. Here, we have applied infrared nanospectroscopy ...
Oxford University Press (OUP)2019Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis
Jacques Fellay, Christian Axel Wandall Thorball
Fc receptor (FcR) genes collectively have copy number and allelic polymorphisms that have been implicated in multiple inflammatory and autoimmune diseases. This variation might also be involved in etiology of infectious diseases. The protective role of Fc- ...
2019Signatures of selection and environmental adaptation across the goat genome post-domestication
Stéphane Joost, Estelle Rochat
Background: Since goat was domesticated 10,000 years ago, many factors have contributed to the differentiation of goat breeds and these are classified mainly into two types: (i) adaptation to different breeding systems and/or purposes and (ii) adaptation t ...
BMC2018