Concept
Immunosenescence
Related publications (43)
Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond
The use of CAR technologies has revolutionized cancer treatment. Their unprecedented efficacy against B cell malignancies has opened the doors for a lot of excitement and research in the field. These synthetic receptors are composed of an antigen recogniti ...
EPFL2023Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma
Didier Trono, Priscilla Turelli, Marc Emmenegger
The clinical outcome of SARS-CoV-2 infections, which can range from asymptomatic to lethal, is crucially shaped by the concentration of antiviral antibodies and by their affinity to their targets. However, the affinity of polyclonal antibody responses in p ...
LIFE SCIENCE ALLIANCE LLC2022Cytokine engineering for targeted cancer immunotherapy
Cytokines are key modulators of the immune responses and represent promising therapeutics for a variety of cancers. However, successful translation of cytokine-based therapy to the clinic is limited by, among others, severe toxicities and lack of efficacy ...
2021Synthesis and characterizations of biocompatible polymers and carbon nanotubes-based hybrids for biomedical applications
The outstanding physico-chemical properties of carbon nanotubes (CNTs) applied to rectify the problems in bone tissue engineering through enhancing cell proliferation, adhesion and viability, which lead to the improvement in bone replacement, growth and he ...
2020Weevil pgrp-lb prevents endosymbiont TCT dissemination and chronic host systemic immune activation
Long-term intracellular symbiosis (or endosymbiosis) is widely distributed across invertebrates and is recognized as a major driving force in evolution. However, the maintenance of immune homeostasis in organisms chronically infected with mutualistic bacte ...
2019Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity
Identifying the drivers of the observed interindividual variability of the human immune system is crucial to our understanding of infectious and immune-mediated diseases. The contribution of genetic and non-genetic factors to immunological differences betw ...
EPFL2018