Publications related to Drug liberalization

A streamlined search technology for identification of synergistic drug combinations

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska

A major key to improvement of cancer therapy is the combination of drugs. Mixing drugs that already exist on the market may offer an attractive alternative. Here we report on a new model-based streamlined feedback system control (s-FSC) method, based on a ...

Nature Publishing Group2015

Chiral gamma-Lactams by Enantioselective Palladium(0)-Catalyzed Cyclopropane Functionalizations

Nicolai Cramer, Julia Pedroni

Cyclopropanes fused to pyrrolidines are important structural features found in a number of marketed drugs and development candidates. Typically, their synthesis involves the cyclopropanation of a dihydropyrrole precursor. Reported herein is a complementary ...

Wiley-V C H Verlag Gmbh2015

Linking electricity prices and costs in bottom-up top-down coupling under changing market environments

Philippe Thalmann, Frank Vöhringer, Sophie Maire

We couple top-down and bottom-up models to analyse electricity markets. We simulate energy policies under alternative regulatory assumptions. We shows that market liberalisation affects the links between generation costs and user prices. We show that the c ...

EPFL LEURE2015

Mode of Action of Clofazimine and Combination Therapy with Benzothiazinones against Mycobacterium tuberculosis

Stewart Cole, Benoit Lechartier

Clofazimine (CZM) is an antileprosy drug that was recently repurposed for treatment of multidrug-resistant tuberculosis. In Mycobacterium tuberculosis, CZM appears to act as a prodrug, which is reduced by NADH dehydrogenase (NDH-2), to release reactive oxy ...

Amer Soc Microbiology2015

The consensus molecular subtypes of colorectal cancer

Douglas Hanahan, Krisztian Homicsko, Sarah Gerster, Paolo Angelino, Mauro Delorenzi, Anguraj Sadanandam, Xin Wang

Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC classifications and facilitate clinical translation, we formed an international c ...

Nature Publishing Group2015

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

John McKinney, Neeraj Dhar, Muhittin Emre Özdemir, Ping Lu

Bedaquiline (BDQ), an ATP synthase inhibitor, is the first drug to be approved for treatment of multidrug-resistant tuberculosis in decades. Though BDQ has shown excellent efficacy in clinical trials, its early bactericidal activity during the first week o ...

Nature Publishing Group2014

Safe Implementation of Embedded Software for a Portable Device Supporting Drug Administration

Giovanni De Micheli, Yann Thoma, Alena Simalatsar, Wenqi You Dubout

Poor adherence to medical regimen causes approximately 33% to 69% of medication-related hospitalizations and accounts for $100 billion in annual health care costs. In this paper we address the problem of unintentional non adherence, when patient fails to t ...

IEEE2014

Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel

László Forró, Andrzej Sienkiewicz, Katarzyna Pierzchala

We have investigated drug loading and release from thermosensitive gel emulsions with external triggering by an alternating magnetic field (AMF) for on-demand drug delivery. Superparamagnetic iron oxide nanoparticles dispersed in gel emulsions were used to ...

Amer Inst Physics2014

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Drug liberalization

A streamlined search technology for identification of synergistic drug combinations

Chiral gamma-Lactams by Enantioselective Palladium(0)-Catalyzed Cyclopropane Functionalizations

Linking electricity prices and costs in bottom-up top-down coupling under changing market environments

Mode of Action of Clofazimine and Combination Therapy with Benzothiazinones against Mycobacterium tuberculosis

The consensus molecular subtypes of colorectal cancer

Self-folding mobile microrobots for biomedical applications

How Accurately Can We Predict the Melting Points of Drug-like Compounds?

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

Safe Implementation of Embedded Software for a Portable Device Supporting Drug Administration

Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel

Graph Chatbot

Chat with Graph Search

Linking electricity prices and costs in bottom-up top-down coupling under changing market environments

Mode of Action of Clofazimine and Combination Therapy with Benzothiazinones against Mycobacterium tuberculosis

Chiral gamma-Lactams by Enantioselective Palladium(0)-Catalyzed Cyclopropane Functionalizations

Self-folding mobile microrobots for biomedical applications

A streamlined search technology for identification of synergistic drug combinations

The consensus molecular subtypes of colorectal cancer

How Accurately Can We Predict the Melting Points of Drug-like Compounds?

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

Safe Implementation of Embedded Software for a Portable Device Supporting Drug Administration

Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel