Concept

Dwarfism

Related publications (9)

TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin

Pierre Gönczy, Coralie Busso, Benita Wolf, Fernando Romero Balestra, Tessa Vivianne Averink, Alizée Buff

TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ growth and increased tumor formation. TRIM37 depletion from tissue culture cells results in supernumerary foci bearing the centriolar protein Centrin. Here, we chara ...

ELIFE SCIENCES PUBLICATIONS LTD2021

Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations

Denis Duboule, Lucille Delisle, Christopher Chase Bolt

Mesomelic dysplasia, a severe shortening and bending of the limb, has been linked to rearrangements in the HoxD cluster in humans and mice. Here the authors engineer a 1 Mb inversion including the HoxD gene cluster and use this model to provide a mechanist ...

NATURE PORTFOLIO2021

“HabERi”, une nouvelle forme d'habitat évolutif pour réfugiés

Stephanie Roux

Située à moins de 10 km des côtes turques, l'île grecque de Lesbos est récemment devenue l'une des plus importantes portes d'entrée dans l'Union européenne ouvertes aux migrants. Avec des conflits mondiaux qui perdurent de plus en plus, les arrivées massiv ...

2017

Early life exposure to PCB126 results in delayed mortality and growth impairment in the zebrafish larvae

Kristin Schirmer

The occurrence of chronic or delayed toxicity resulting from the exposure to sublethal chemical concentrations is an increasing concern in environmental risk assessment. The Fish Embryo Toxicity (FET) test with zebrafish provides a reliable prediction of a ...

Elsevier Science Bv2015

Defining the role of common variation in the genomic and biological architecture of adult human height

Jiancheng Yang, Murielle Bochud, Zhaoming Wang

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that th ...

Nature Publishing Group2014

Modeling of peritectic coupled growth in Cu-Sn alloys

Michel Rappaz, Jonas Valloton, Jonathan Dantzig

In directional solidification experiments on hypoperitectic Cu-Sn alloys at low velocity and high thermal gradient, both lamellar and fibrous coupled peritectic growth patterns have been observed. Two phenomena that had not been observed in previous experi ...

Elsevier2013

A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development

Denis Duboule

Deficiencies or mutations in the human pseudoautosomal SHOX gene are associated with a series of short-stature conditions, including Turner syndrome, Leri-Weill dyschondrosteosis, and Langer mesomelic dysplasia. Although this gene is absent from the mouse ...

2006

Differential effect of thyroid hormone deficiency on the growth of calretinin-expressing neurons in rat spinal cord and dorsal root ganglia

Pierre Magistretti, Thibault Adrien Kuntzer

The development of spinal cord or dorsal root ganglia neurons expressing calretinin (CR) was studied in thyroid hormone-deficient rats. Immunocytochemical and morphometric analyses showed that the hypothyroidism induced a significant decrease in the number ...

2000

VEGF is required for growth and survival in neonatal mice

Freddy Radtke, Michel Aguet

We employed two independent approaches to inactivate the angiogenic protein VEGF in newborn mice: inducible, Cre-loxP- mediated gene targeting, or administration of mFlt(1-3)-IgG, a soluble VEGF receptor chimeric protein. Partial inhibition of VEGF achieve ...

1999

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