Sepphoris (sᵻˈfɔːrᵻs ; Sépphōris), known in Hebrew as Tzipori (צִפּוֹרִי Ṣīppōrī) and in Arabic as Saffuriya (صفورية ) since the 7th century, is an archaeological site located in the central Galilee region of Israel, north-northwest of Nazareth. It lies above sea level and overlooks the Beit Netofa Valley. The site holds a rich and diverse historical and architectural legacy that includes Hellenistic, ancient Jewish, Roman, Byzantine, early Islamic, Crusader, Mamluk and Ottoman remains. In the Roman period, it was also called Diocaesaraea. In Mandatory Palestine, Saffuriya was a Palestinian Arab town with a population of approximately 5000 people at the time of its depopulation in 1948.
Since Late Antiquity, it was believed to be the birthplace of Mary, mother of Jesus, and the village where Saints Anna and Joachim are often said to have resided, where today a fifth-century basilica is excavated at the site honouring the birth of Mary. Notable structures at the site include a Roman theatre, two early Christian churches, a Crusader fort partly rebuilt by Zahir al-Umar in the 18th century, and over sixty different mosaics dating from the third to the sixth century CE.
Following the Bar Kokhba revolt of 132–135, Sepphoris was one of the Galilean centers where rabbinical families from neighboring Judea relocated. Remains of a synagogue dated to the first half of the fifth century were discovered on the northern side of town. In the 7th century, the town was conquered by the Arab Rashidun armies during the Muslim conquest of the Levant. Successive Muslim dynasties ruled the area until the Crusades.
Until its depopulation during the 1948 Arab–Israeli War, Saffuriya was a Palestinian Arab village. Moshav Tzippori was established adjacent to the site in 1949. It falls under the jurisdiction of Jezreel Valley Regional Council, and in had a population of .
The area where the remains of the ancient city have been excavated, occupied until 1948 by the Arab village, was designated an archaeological reserve named Tzipori National Park in 1992.