Concept
Molecular epidemiology
Related publications (52)
Enabling Stroke Theranostics with Hyperpolarized Magnetic Resonance
The severe social and economic burden of stroke is a strong motivation for the exploration of innovative medical approaches. In this context, magnetic resonance (MR) of hyperpolarized (HP) molecular agents via dissolution dynamic nuclear polarization (dDNP ...
EPFL2023Upregulation of the ERR γ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis
Johan Auwerx, Changmyung Oh, Jiale Wang
Emerging evidence suggest that transcription factors play multiple roles in the development of pancreatitis, a necroinflammatory condition lacking specific therapy. Estrogen-related receptor γ (ERRγ), a pleiotropic transcription factor, has been reported t ...
NATL ACAD SCIENCES2023The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators
Johan Auwerx, Richardus Houtkooper, Maroun Bou Sleiman, Xu Wang, Pooja Jha
Many genes and pathways have been linked to aging, yet our understanding of underlying molecular mechanisms is still lacking. Here, we measure changes in the transcriptome, histone modifications, and DNA methylome in three metabolic tissues of adult and ag ...
2020