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Nucleosome depletion at transcription start sites (TSS) has been documented genome-wide in multiple eukaryotic organisms. However, the mechanisms that mediate this nucleosome depletion and its functional impact on transcription remain largely unknown. We h ...
The mechanism of chromatin compaction in mitosis has been well studied, while little is known about what controls chromatin decompaction in early G1 phase. We have localized the Condensin subunit Brn1 to a compact spiral of rDNA in mitotic budding yeast ce ...
KAP1 is an essential cofactor of KRAB-zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. Here, we report that KAP1 is expressed at high levels and ...
One of the central questions in eukaryotic transcription is how activators can transmit their signal to stimulate gene expression in the context of chromatin. The multisubunit SAGA coactivator complex has both histone acetyltransferase and deubiquitination ...
The inhibitors of growth (ING) family of tumor suppressors consists of five homologous proteins involved in chromatin remodeling. They form part of different acetylation and deacetylation complexes and are thought to direct them to specific regions of the ...
American Society for Biochemistry and Molecular Biology2008
This paper proposes modifications to the Multi-resolution RASTA (MRASTA) feature extraction technique for the automatic speech recognition (ASR). By emulating asymmetries of the temporal receptive field (TRF) profiles of auditory mid-brain neurons, we obta ...
This paper proposes modifications to the Multi-resolution RASTA (MRASTA) feature extraction technique for the automatic speech recognition (ASR). By emulating asymmetries of the temporal receptive field (TRF) profiles of auditory mid-brain neurons, we obta ...
Sirtuins (Sirts) compose a family of NAD(+)-dependent deacetylases and/or ADP-ribosyltransferases, which have been implicated in aging, metabolism, and tolerance to oxidative stress. Many of the biological processes regulated by Sirts result from the adapt ...
This paper proposes modifications to the Multi-resolution RASTA (MRASTA) feature extraction technique for the automatic speech recognition (ASR). By emulating asymmetries of the temporal receptive field (TRF) profiles of higher level auditory neurons, we o ...
Springer-Verlag New York, Ms Ingrid Cunningham, 175 Fifth Ave, New York, Ny 10010 Usa2008
Epigenetic alterations during tumor formation and progression have become an increasingly important aspect of cancer biology. Loss of global methylation at histone H4 lysine 20, mediated by the Suv4-20 HMTases, and loss of methylation at histone H3 lysine ...
