Concept

African trypanosomiasis

Related publications (10)

Synthesis of diphenoxyadamantane alkylamines with pharmacological interest

In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpi ...

PERGAMON-ELSEVIER SCIENCE LTD2019

Biogenesis of the mitochondrial DNA inheritance machinery in the mitochondrial outer membrane of Trypanosoma brucei

Mathilde Stéphanie Willemin, André Schneider

Mitochondria cannot form de novo but require mechanisms that mediate their inheritance to daughter cells. The parasitic protozoan Trypanosoma brucei has a single mitochondrion with a single-unit genome that is physically connected across the two mitochondr ...

2017

Genomic diversity and disease prevalence in Ugandan cattle

Stéphane Joost, Sylvie Stucki, Elia Vajana, Pierre Taberlet

Ugandan cattle are represented by three main types: the long-horned Ankole, the short-horned zebu, and the Ankole-zebu crosses called “Nganda”. In the course of the EU-funded project Nextgen, Ugandan cattle have been extensively sampled over the whole coun ...

2015

Flagellar membranes are rich in raft-forming phospholipids

Adrian Schmid

The observation that the membranes of flagella are enriched in sterols and sphingolipids has led to the hypothesis that flagella might be enriched in raft-forming lipids. However, a detailed lipidomic analysis of flagellar membranes is not available. Novel ...

Company Of Biologists Ltd2015

Suppressed convective rainfall by agricultural expansion in southeastern Burkina Faso

Marc Parlange, Gabriel George Katul, Natalie Claire Ceperley, Theophile Mande, Scott W. Tyler

With the green economy being promoted as a path to sustainable development and food security within the African continent, the influx of agricultural land is proliferating at a rapid pace often replacing natural savannah forests. Where agriculture is prima ...

American Geophysical Union2015

Antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation

Stewart Cole, Rosario Scopelliti, Luc Patiny, Karl Gademann, Simone Bonazzi

The synthesis of nine nostocarboline derivatives with substitutions of the 2-methyl group by alkyl, aryl and functionalized residues, 10 symmetrical bis cationic dimers linking 6-Cl-norharmane through the 2-position and fifteen derivatives of the marine al ...

2010

Biologically active secondary metabolites from cyanobacteria

Cyril Portmann

For millennia, nature was the only source of medicine for mankind. Even today natural products represent a large proportion of the drugs in use. In some areas, like cancer or infectious diseases, about 50 % of the compounds used are of natural origin. Cyan ...

EPFL2010

Isolation of Aerucyclamides C and D and Structure Revision of Microcyclamide 7806A: Heterocyclic Ribosomal Peptides from Microcystis aeruginosa PCC 7806 and Their Antiparasite Evaluation

Cyril Portmann, Karl Gademann

Aerucyclamides C and D were isolated from the cyanobacterium Microcystis aeruginosa PCC 7806, and their structures established by NMR spectroscopy and chemical transformation and degradation. Acidic hydrolysis of aerucyclamide C (CF3CO2H, H2O) resulted in ...

2008

Modules d'endo-permutation

Nadia Mazza

If p is an odd prime, the group of endo-trivial modules for a metacyclic p-group is infinite cyclic generated by the Heller translate of the trivial module. The structure of the whole Dade group of endo-permutation modules can be deduced from this. Every k ...

Université de Lausanne2003

The glycan core of GPI-anchored proteins modulates aerolysin binidng but is not sufficient: the polypeptide moiety is required for the toxin-receptor interaction

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

Sensitivity of mammalian cells to the bacterial toxin aerolysin is due to the presence at their surface of glycosylphosphatidyl inositol (GPI)-anchored proteins which act as receptors. Using a panel of mutants that are affected in the GPI biosynthetic path ...

2002

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