Concept

Fentanyl

Related publications (11)

Cysteine-Cysteine Cross-Conjugation of both Peptides and Proteins with a Bifunctional Hypervalent Iodine-Electrophilic Reagent

Jérôme Waser, Stefano Nicolai, Abhaya Kumar Mishra

Peptide and protein bioconjugation sees ever-growing applications in the pharmaceutical sector. Novel strategies and reagents that can address the chemo- and regioselectivity issues inherent to these biomolecules, while delivering stable and functionalizab ...

Weinheim2023

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Quadruped animal locomotion emerges from the interactions between the spinal central pattern generator (CPG), sensory feedback, and supraspinal drive signals from the brain. Computational models of CPGs have been widely used for investigating the spinal co ...

New York2023

Cortico-muscular connectivity is modulated by passive and active Lokomat-assisted Gait

Silvestro Micera, Fiorenzo Artoni

The effects of robotic-assisted gait (RAG) training, besides conventional therapy, on neuroplasticity mechanisms and cortical integration in locomotion are still uncertain. To advance our knowledge on the matter, we determined the involvement of motor cort ...

Berlin2023

IoT Bio-Electronic Multi-Panel Device for On-line Monitoring of Anaesthesia Delivery

Francesca Stradolini

After a failure of "One-Size-Fits-All" approach on traditional treatment of diseases, the age of multi-faceted personalized medicine came into being for tailoring therapy to get the best response in the highest safety margin. Personalized drug dosage is on ...

EPFL2018

We describe the computational design of proteins that bind the potent analgesic fentanyl. Our approach employs a fast docking algorithm to find shape complementary ligand placement in protein scaffolds, followed by design of the surrounding residues to opt ...

Elife Sciences Publications Ltd2017

Energy metabolism in the rat cortex under thiopental anaesthesia measured

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay

Barbiturates, commonly used as general anaesthetics, depress neuronal activity and thus cerebral metabolism. Moreover, they are likely to disrupt the metabolic support of astrocytes to neurons, as well as the uptake of nutrients from circulation. By employ ...

Wiley-Blackwell2017

Size and Viewpoint of an Embodied Virtual Body Affect the Processing of Painful Stimuli

Olaf Blanke, Joan Llobera Mahy

Looking at one's own body might induce visual analgesia. However, the cognitive and physiological mechanisms underlying such visual analgesia are unknown. Because body and pain representations in the brain are multisensory, and have been reported to partia ...

Churchill Livingstone2015

Arene ruthenium and pentamethylcyclopentadienyl rhodium and iridium complexes containing N,O-chelating ligands derived from piroxicam: Synthesis, molecular structure and cytotoxicity

Paul Joseph Dyson, Tina Riedel

The non-steroidal anti-inflammatory and anti-arthritic drug piroxicam (LH) reacts with arene ruthenium dichloride dimers in refluxing dichloromethane to give the complexes [(eta(6)-arene)Ru(eta(2)-N,O-L)Cl] (3: arene = C6H5Me, 4: arene = p-MeC6H4Pri, 5: ar ...

Elsevier2014

Monitoring of illicit pill distribution networks using an image collection exploration framework

Luc Patiny, Julien Wist

This paper proposes a novel approach for the analysis of illicit tablets based on their visual characteristics. In particular, the paper concentrates on the problem of ecstasy pill seizure profiling and monitoring. The presented method extracts the visual ...

Elsevier Ireland Ltd2012

A Short and Convenient Synthesis of 1-Deoxymannojirimycin (DMJ) and N-oxy-Analogues from D-Fructose

Pierre Vogel, Sandrine Gerber, Claudia Bello

The ketonitrone 8 was prepared from D-fructose as an inexpensive starting material, and was used in a stereoselective synthesis of 1-deoxymannojirimycin (4), its previously unknown N-hydroxy analogue 15, as well as the polyhydroxylated ketonitrone 14. The ...

2009

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