Concept
Ossification
Related publications (66)
Synergetic Support of Cartilage Homeostasis via Coupled Thermal-Hydrostatic Pressure Stimuli
Cartilage homeostasis, crucial for musculoskeletal function, is orchestrated by interconnected biophysical cues. In healthy cartilage, repetitive compressive loading not only elicits a range of mechanical stimuli but also induces a gradual transient temper ...
EPFL2024Premature Vertebral Mineralization in hmx1-Mutant Zebrafish
H6 family homeobox 1 (HMX1) regulates multiple aspects of craniofacial development, and mutations in HMX1 are linked to an ocular defect termed oculoauricular syndrome of Schorderet-Munier-Franceschetti (OAS) (MIM #612109). Recently, additional altered oro ...
2022Age- and sex-specific normative values of bone mineral density in the adult glenoid
Dominique Pioletti, Alexandre Terrier, Alain Farron, Patrick Goetti, Frédéric Vauclair, Philippe Büchler
The objective of this study was to determine the normative bone mineral density (BMD) of cortical and trabecular bone regions in the adult glenoid and its dependence on the subject's age and sex. We analyzed computed tomography (CT) scans of 441 shoulders ...
WILEY2022SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation
Johan Auwerx, Dongryeol Ryu, Olivier Staub, Lilia Noriega Lopez
SIRT7 is a NAD(+)-dependent deacetylase that controls important aspects of metabolism, cancer, and bone formation. However, the molecular targets and functions of SIRT7 in the kidney are currently unknown. In silico analysis of kidney transcripts of the BX ...
2021Morphomechanical Model Of The Torsional C-Looping In The Embryonic Heart
Before septation processes shape its four chambers, the embryonic heart is a straight tube that spontaneously bends and twists breaking the left-right symmetry. In particular, the heart tube is subjected to a cell remodeling inducing ventral bending and de ...
SIAM PUBLICATIONS2021Deep learning for the rapid automatic quantification and characterization of rotator cuff muscle degeneration from shoulder CT datasets
Alexandre Terrier, Alain Farron, Elham Taghizadeh, Philippe Büchler
Objectives This study aimed at developing a convolutional neural network (CNN) able to automatically quantify and characterize the level of degeneration of rotator cuff (RC) muscles from shoulder CT images including muscle atrophy and fatty infiltration. M ...
SPRINGER2020Sub-trabecular strain evolution in human trabecular bone
Goran Lovric, Alessandra Patera
To comprehend the most detrimental characteristics behind bone fractures, it is key to understand the material and tissue level strain limits and their relation to failure sites. The aim of this study was to investigate the three-dimensional strain distrib ...
NATURE RESEARCH2020Effect of temporal onsets of mechanical loading on bone formation inside a tissue engineering scaffold combined with cell therapy
Dominique Pioletti, Tanja Cloé Hausherr
Several approaches to combine bone substitutes with biomolecules, cells or mechanical loading have been explored as an alternative to the limitation and risk-related bone auto- and allo-grafts. In particular, human bone progenitor cells seeded in porous po ...
2018Non-setting, injectable biomaterials containing particulate hydroxyapatite can increase primary stability of bone screws in cancellous bone
Dominique Pioletti, Ulrike Kettenberger, Jorge Solana Munoz
BACKGROUND: Fracture fixation in weak bone is still a clinical challenge. Screw augmentation was shown to successfully increase their primary stability. The currently used calcium phosphate or polymeric bone cements, however, present important drawbacks su ...
2018Create a Finite Element model of experiment involving cadaveric scapulae
Hypothesis: Nowadays, the number of people suffering from shoulder osteoarthritis increases as the population is ageing. An end-stage treatment is the total shoulder arthroplasty (TSA), but it still suffers from a high failure rate in comparison to other j ...
2018