Concept

Computational biology

Related publications (422)

Adaptive Models for Gene Networks

Biological systems are often treated as time-invariant by computational models that use fixed parameter values. In this study, we demonstrate that the behavior of the p53-MDM2 gene network in individual cells can be tracked using adaptive filtering algorit ...

Public Library of Science2012

Massively parallel measurements of molecular interaction kinetics on a microfluidic platform

Sebastian Maerkl, Marcel Geertz

Quantitative biology requires quantitative data. No high-throughput technologies exist capable of obtaining several hundred independent kinetic binding measurements in a single experiment. We present an integrated microfluidic device (k-MITOMI) for the sim ...

Natl Acad Sciences2012

Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition

Pierre Vogel, Somi Reddy Majjigapu, Olivier Michielin

Indoleamine 2,3-dioxygenase 1 (IDO1) is an important therapeutic target treatment of diseases such as cancer that involve pathological immune escape. Starting from the scaffold of our previously discovered IDO1 inhibitor 4-phenyl-1,2,3-triazole, we used co ...

2012

A Spectroscopic and Computational Study of a Photoinduced Cross-Dehydrogenative Coupling Reaction of a Stable Semiquinone Radical

Chenyi Yi, Jakob Grilj, Eric Vauthey

Norrish-type-II reaction on a semiquinone radical: Stable semiquinone radicals serve as novel molecular platforms on which a Norrish-type-II photoreaction can be initiated. A detailed reaction scheme involving a 1,5-hydrogen transfer followed by a cyclizat ...

Wiley-V C H Verlag Gmbh2012

Improving the study of proton transfers between amino acid side chains in solution: choosing appropriate DFT functionals and avoiding hidden pitfalls

Marta Andreia Da Silva Perez

We have studied the influence of implicit solvent models, inclusion of explicit water molecules, inclusion of vibrational effects, and density functionals on the quality of the predicted pK a of small amino acid side chain models. We found that the inclusi ...

2012

Code Sharing Is Associated with Research Impact in Image Processing

Patrick Vandewalle

In computational sciences such as image processing, publishing usually isn’t enough to allow other researchers to verify results. Often, supplementary materials such as source code and measurement data are required. Yet most researchers choose not to make ...

2012

Neural Network-Based Thermal Simulation of Integrated Circuits on GPUs

David Atienza Alonso, Arvind Raj Mahankali Sridhar, Martino Ruggiero, Alessandro Vincenzi

With the rising challenges in heat removal in integrated circuits (ICs), the development of thermal-aware computing architectures and run-time management systems have become indispensable to the continuation of IC design scaling. These thermal-aware design ...

Institute of Electrical and Electronics Engineers2012

Digital holographic microscopy for the cytomorphological imaging of cells under zero gravity

Christian Depeursinge, Muhammed Fatih Toy, Marcel Egli, Stéphane Richard

Digital holographic microscopy (DHM) has been gaining interest from cell biology community because of its label free nature and quantitative phase signal output. Besides, fast shutter time, image reconstruction by numerical propagation of the wave fields, ...

Spie-Int Soc Optical Engineering, Po Box 10, Bellingham, Wa 98227-0010 Usa2012

Joint Detection and Localization of Multiple Speakers using a Probabilistic Interpretation of the Steered Response Power

Detection and localization of multiple speakers in a noisy and reverberant environment is a fundamental and difficult task. In the literature, steered response power (SRP) based techniques are typically used to accomplish this task which can be computation ...

2012

Certified Reduced Basis Method for Parametrized Partial Differential Equations: a Combination with ANOVA Expansion

Denis Devaud

In many fields, the computation of an output depending on a field variable is of great interest. If the field variable depends on a high-dimensional parameter, the computational cost involved can be huge. Hence, it is necessary to find efficient and reliab ...

2012

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