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In humans, a severe spinal cord contusion interrupts the vast majority of supraspinal projections to the spinal cord below the lesion. Permanent paralysis results from the chronic failure of these spared projections to engage lumbar circuits producing leg ...
Many manipulations in human everyday activities rely on the collaboration of our two hands. Bimanual fine manipulation tasks are particularly demanding as precise coordination among fingers of both hands is required. Yet, despite the abundant degrees of fr ...
Spinal cord injury (SCI) is a life-changing event. People who suffer from it lose their abilityto move normally and are subject to life-threatening symptoms. When the insult is not toosevere, partial recovery is possible. Otherwise, for severely affected p ...
Background Rehabilitative treatment plans after stroke are based on clinical examinations of functional capacity and patient-reported outcomes. Objective information about daily life performance is usually not available, but it may improve therapy personal ...
Tourette syndrome is characterized by 'unvoluntary' tics, which are compulsive, yet often temporarily suppressible. The inferior frontal gyms is implicated in motor control, including inhibition of pre-potent actions through influences on downstream subcor ...
The brain processes sensory information in a context- and learning-dependent manner for adaptive behavior. Through reward-based learning, relevant sensory stimuli can become linked to execution of specific actions associated with positive outcomes. The neu ...
In the present work, we approach two key aspects of memory formation: associative memory and synaptic consolidation.
The storage of associative memory is commonly related to the medial temporal lobe in humans. Experimental evidence shows that the memories ...
Many manipulations in human everyday activities rely on the collaboration of our two hands. Bimanual fine manipulation tasks are particularly demanding as precise coordination among fingers of both hands is required. Yet, despite the abundant degrees of fr ...
The opportunistic pathogen Pseudomonas aeruginosa explores surfaces using twitching motility powered by retractile extracellu-lar filaments called type IV pili (T4P). Single cells twitch by sequen-tial T4P extension, attachment, and retraction. How single ...
Humans have a distinguishing ability for fine motor control that is subserved by a highly evolved cortico-motor neuronal network. The acquisition of a particular motor skill involves a long series of practice movements, trial and error, adjustment and refi ...
