Publications related to Combination therapy

Preclinical combination therapy of the investigational drug NAMI-A(+) with doxorubicin for mammary cancer

Paul Joseph Dyson, Tina Riedel, Gianni Sava

Aim of the study The tumor metastases targeting ruthenium complex NAMI-A synergistically improves the activity of gemcitabine in combination therapies. High-throughput screening was used to identify other potential drug combinations from a library of FDA a ...

Springer2015

A streamlined search technology for identification of synergistic drug combinations

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska

A major key to improvement of cancer therapy is the combination of drugs. Mixing drugs that already exist on the market may offer an attractive alternative. Here we report on a new model-based streamlined feedback system control (s-FSC) method, based on a ...

Nature Publishing Group2015

Combinations of beta-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

John McKinney, Neeraj Dhar

We report here a dehydropeptidase-deficient murine model of tuberculosis (TB) infection that is able to partially uncover the efficacy of marketed broad-spectrum beta-lactam antibiotics alone and in combination. Reductions of up to 2 log CFU in the lungs o ...

American Society for Microbiology2015

CNT and proteins for bioelectronics in personalized medicine

Giovanni De Micheli, Sandro Carrara, Cristina Boero, Andrea Cavallini

From their discovery, CNTs have increasingly attracted interest because of their peculiar electrical, mechanical, and chemical properties. In 1991, Sumio Iijima first observed and described in detail the atomic arrangement of this new type of carbon struct ...

Cambridge University Press2015

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

Paul Joseph Dyson, Stewart Cole, Florence Pojer, Ruben Hartkoorn, Anthony Vocat, Ming Zhang, Joao Pedro De Almeida Neres, Thierry Buclin, Benoit Lechartier

The benzothiazinone lead compound, BTZ043, kills Mycobacterium tuberculosis by inhibiting the essential flavo-enzyme DprE1, decaprenylphosphoryl-beta-D-ribose 2-epimerase. Here, we synthesized a new series of piperazine-containing benzothiazinones (PBTZ) a ...

2014

In Vitro and In Vivo Activities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis

Stewart Cole, Neeraj Dhar, Claudia Sala, Anthony Vocat, Ming Zhang

Oxazolidinones represent a new class of antituberculosis drugs that exert their function by inhibiting protein synthesis. Here, we compared the activities of three oxazolidinones, linezolid, PNU-100480, and AZD5847, against latent tuberculosis using a simp ...

Amer Soc Microbiology2014

Continuous monitoring of Naproxen by a cytochrome P450-based electrochemical sensor

Giovanni De Micheli, Sandro Carrara, Andrea Cavallini, Camilla Baj-Rossi

This paper reports the characterization of an electrochemical biosensor for the continuous monitoring of Naproxen based on cytochrome P450. The electrochemical biosensor is based on the drop-casting of multi-walled carbon-nanotubes (MWCNTs) and microsomal ...

Elsevier2014

It is All About Proteases: From Drug Delivery to In Vivo Imaging and Photomedicine

Hubert van den Bergh

Clinical studies provide overwhelming evidence for the importance of proteolytic imbalance and the upregulation of diverse protease classes in diseases such as cancer and arthritis. While the complex nature of proteolytic networks has hampered the developm ...

Bentham Science Publishers2011

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Combination therapy

Preclinical combination therapy of the investigational drug NAMI-A(+) with doxorubicin for mammary cancer

A streamlined search technology for identification of synergistic drug combinations

Combinations of beta-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

CNT and proteins for bioelectronics in personalized medicine

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

In Vitro and In Vivo Activities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis

Targeting HIV-related Medication Side Effects and Sentiment Using Twitter Data

Continuous monitoring of Naproxen by a cytochrome P450-based electrochemical sensor

It is All About Proteases: From Drug Delivery to In Vivo Imaging and Photomedicine

Multi-stream Features Combination based on Dempster-Shafer Rule for LVCSR System

Graph Chatbot

Chat with Graph Search

CNT and proteins for bioelectronics in personalized medicine

Preclinical combination therapy of the investigational drug NAMI-A(+) with doxorubicin for mammary cancer

Combinations of beta-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

A streamlined search technology for identification of synergistic drug combinations

In Vitro and In Vivo Activities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis

Targeting HIV-related Medication Side Effects and Sentiment Using Twitter Data

Continuous monitoring of Naproxen by a cytochrome P450-based electrochemical sensor

Multi-stream Features Combination based on Dempster-Shafer Rule for LVCSR System

It is All About Proteases: From Drug Delivery to In Vivo Imaging and Photomedicine