Concept
Myopathy
Related publications (24)
Cyclo His-Pro Attenuates Muscle Degeneration in Murine Myopathy Models
Johan Auwerx, Xiaoxu Li, Tanes Imamura de Lima, Keno Strotjohann, Alessia De Masi
Among the inherited myopathies, a group of muscular disorders characterized by structural and metabolic impairments in skeletal muscle, Duchenne muscular dystrophy (DMD) stands out for its devastating progression. DMD pathogenesis is driven by the progress ...
Wiley2024Mitophagy Activation by Urolithin A to Target Muscle Aging
The age-related loss of skeletal muscle function starts from midlife and if left unaddressed can lead to an impaired quality of life. A growing body of evidence indicates that mitochondrial dysfunction is causally involved with muscle aging. Muscles are ti ...
New York2023Assessment of idiopathic inflammatory myopathy using a deep learning method for muscle T2 mapping segmentation
Qian Wang, Tobias Kober, Tom Hilbert, Yao Zhang, Yubo Zhao
Objective To investigate the utility of an automatic deep learning (DL) method for segmentation of T2 maps in patients with idiopathic inflammatory myopathy (IIM) against healthy controls, and also the association of quantitative T2 values in patients with ...
SPRINGER2022Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease
Loss of mitochondrial function and proteostasis typify aging and age-associated degenerative disorders such as Alzheimer's disease and muscle aging. To date, no cure or preventive measure is available to manage these conditions. Alterations of cellular pro ...
EPFL2021Metabolic rescue of muscle and muscle stem cells in muscle disease
Duchenne muscular dystrophy (DMD), caused by the mutation of dystrophin gene, is an X-linked disorder that affects 1 in 3500 males, leading to progressive muscle degeneration and eventually resulting in premature death. Increasing evidence indicates that D ...
EPFL2020Deep learning for the rapid automatic quantification and characterization of rotator cuff muscle degeneration from shoulder CT datasets
Alexandre Terrier, Alain Farron, Elham Taghizadeh, Philippe Büchler
Objectives This study aimed at developing a convolutional neural network (CNN) able to automatically quantify and characterize the level of degeneration of rotator cuff (RC) muscles from shoulder CT images including muscle atrophy and fatty infiltration. M ...
SPRINGER2020Wearable exoskeletons to support ambulation in people with neuromuscular diseases, design rules and control
Neuromuscular diseases are degenerative and, thus far, incurable disorders that lead to large muscle wasting. They result in constant deterioration of activities of daily living and in particular of ambulation. Some common types include Duchenne muscular d ...
EPFL2019Bioengineering the Human Muscle Stem-Cell Niche for Therapeutic Applications
In spite of decades of research, no feasible method for obtaining sufficient numbers of uncommitted muscle stem cells (MuSCs) for therapy of degenerative muscle diseases exists. One of the most fundamental problems associated with stem cell therapy of musc ...
EPFL2019Autologous Cell Therapy Approach for Duchenne Muscular Dystrophy using PiggyBac Transposons and Mesoangioblasts
Duchenne muscular dystrophy (DMD) is a lethal muscle-wasting disease currently without cure. We investigated the use of the PiggyBac transposon for full-length dystrophin expression in murine mesoangioblast (MABs) progenitor cells. DMD murine MABs were tra ...
CELL PRESS2018Upper limb cortical maps in amputees with targeted muscle and sensory reinnervation
Olaf Blanke, Andrea Serino, Michel Akselrod, Wietske Van der Zwaag, Roy Salomon, Giulio Rognini, Roberto Martuzzi, Elisa Canzoneri, Maria Laura Blefari
Neuroprosthetics research in amputee patients aims at developing new prostheses that move and feel like real limbs. Targeted muscle and sensory reinnervation (TMSR) is such an approach and consists of rerouting motor and sensory nerves from the residual li ...
Oxford University Press2017