Publications related to Cellular senescence

The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role in regulating development and homeostasis in various tissues. The cellular processes and events that it controls are diverse, and continued investigation over recen ...

Nature Publishing Group2017

Integration of Metabolic, Regulatory and Signaling Networks Towards Analysis of Perturbation and Dynamic Responses

Vassily Hatzimanikatis, Meriç Ataman, Vikash Kumar Pandey

The expanding generation of dynamic biological data requires approaches that integrate and analyze information from different types of cellular processes –metabolism, regulation, and signaling–, and ultimately increase our insights into the cell behavior u ...

2017

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Johan Auwerx, Davide D'Amico

Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial function and to adapt cellular metabolism to stress. Using a multiomics approach in mammalian cells treated with four types of mitochondrial stressors, we identify ...

Rockefeller Univ Press2017

The role of the equatorial ligands for the redox behavior, mode of cellular accumulation and cytotoxicity of platinum(IV) prodrugs

Hristo Plamenov Varbanov, Sarah Theiner

The current study aims to elucidate the possible reasons for the significantly different pharmacological behavior of platinum(IV) complexes with cisplatin-, carboplatin- or nedaplatin-like cores and how this difference can be related to their main physicoc ...

Elsevier2016

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Johan Auwerx, Kristina Schoonjans, Matthias Lütolf, Davide D'Amico, Dongryeol Ryu, Xu Wang, Hongbo Zhang, Keir Joe Menzies, Karim Laurent Gariani, Peiling Luan, Ruedi Aebersold

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD(+)) and its imp ...

American Association for the Advancement of Science2016

Pro-oxidant effects of nano-TiO2 on Chlamydomonas reinhardtii during short-term exposure

Olivier Martin, Paul Bowen, Christian Santschi, Lionel André Maurizi, Volodymyr Koman, Nadia Rachel Von Moos, Amarnath Jayaprakash

This study sheds light on the short-term dynamics of pro-oxidant processes related to the exposure of C. reinhardtii microalgae to nano-TiO2 using (a) conventional fluorescence probes for cellular pro-oxidant process and (b) a recently developed cytochrome ...

Royal Soc Chemistry2016

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Patrick Fraering, Mitko Dimitrov, Hermeto Gerber, Maria Luna Perciato, Jingjing Chen, Andrea Rinaldi

Activation of NOTCH signalling is associated with advanced prostate cancer and treatment resistance in prostate cancer patients. However, the mechanism that drives NOTCH activation in prostate cancer remains still elusive. Moreover, preclinical evidence of ...

Nature Publishing Group2016

Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species Complex

Marianna Feretzaki

RNAi is a ubiquitous pathway that serves central functions throughout eukaryotes, including maintenance of genome stability and repression of transposon expression and movement. However, a number of organisms have lost their RNAi pathways, including the mo ...

Public Library of Science2016

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Cellular senescence

Notch as a tumour suppressor

Integration of Metabolic, Regulatory and Signaling Networks Towards Analysis of Perturbation and Dynamic Responses

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Disrupting Y-Box-Binding Protein 1 Function Using OSU-03012 Prevents Endometriosis Progression in In Vitro and In Vivo Models

Decellularization of bovine articular cartilage by supercritical carbon dioxide as a matrix for cartilage repair

The role of the equatorial ligands for the redox behavior, mode of cellular accumulation and cytotoxicity of platinum(IV) prodrugs

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Pro-oxidant effects of nano-TiO2 on Chlamydomonas reinhardtii during short-term exposure

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species Complex

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Chat with Graph Search

Disrupting Y-Box-Binding Protein 1 Function Using OSU-03012 Prevents Endometriosis Progression in In Vitro and In Vivo Models

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Notch as a tumour suppressor

The role of the equatorial ligands for the redox behavior, mode of cellular accumulation and cytotoxicity of platinum(IV) prodrugs

Decellularization of bovine articular cartilage by supercritical carbon dioxide as a matrix for cartilage repair

Pro-oxidant effects of nano-TiO2 on Chlamydomonas reinhardtii during short-term exposure

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species Complex

Integration of Metabolic, Regulatory and Signaling Networks Towards Analysis of Perturbation and Dynamic Responses