Concept
Cellular senescence
Related publications (117)
KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification
Pierre Gönczy, Mathias Fournier
Lysine acetylation is a widespread post-translational modification regulating various biological processes. To characterize cellular functions of the human lysine acetyltransferases KAT2A (GCN5) and KAT2B (PCAF), we determined their acetylome by shotgun pr ...
2016Platinum nanopetal-based potassium sensors for acute cell death monitoring
Giovanni De Micheli, Sandro Carrara, Irene Taurino
Growing interest in the role of ions as cell death regulators has led to the consideration of K+, which plays a major role in events such as necrosis, apoptosis and osmotic shock. These mechanisms induce effluxes of K+, which can be m ...
RSC Publishing2016No DDRama at chromosome ends: TRF2 takes centre stage
Antonio Porro, Liuh-Yow Chen, Sascha Feuerhahn
Telomeres are nucleoprotein structures capping the natural termini of eukaryotic linear chromosomes. Telomeres possess an inherent ability to circumvent the activation of a full-blown DNA damage response (DDR), and hence fusion reactions, by limiting inapp ...
Elsevier Science London2015Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
Cathrin Brisken, Melody Swartz, Witold Waldemar Kilarski, Csaba Ferenc László, Elena Menietti, Dania Al Labban
Stromal fibroblast senescence has been linked to ageing-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAFs) are frequently increased. Loss or downmodulation of the Notch effector CSL (also known as RBP-Jκ) in ...
Nature Publishing Group2015Telomere functions grounding on TERRA firma
Long noncoding telomeric repeat-containing RNAs TERRAs - are transcribed in a regulated manner from telomeres throughout eukaryotes. TERRA molecules consist of chromosome end-specific subtelomeric sequences and telomeric repeats at their 3' ends. Recent wo ...
Elsevier Science London2015Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease
Patrick Aebischer, Bernard Schneider, Wojciech Janusz Bobela
Accumulation and misfolding of the alpha-synuclein protein are core mechanisms in the pathogenesis of Parkinson's disease. While the normal function of alpha-synuclein is mainly related to the control of vesicular neurotransmission, its pathogenic effects ...
Mdpi Ag2015Molecularly Engineered Self-Assembling Membranes for Cell-Mediated Degradation
Jeffrey Alan Hubbell, Daniela Sofia Dias Ferreira, Yi-An Lin
The use of peptide engineering to develop self-assembling membranes that are responsive to cellular enzyme activities is reported. The membranes are obtained by combining hyaluronan (HA) and a rationally designed peptide amphiphile (PA) containing a proteo ...
Wiley-Blackwell2015