Concept
Cryoglobulinemia
Related publications (15)
Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes
Tobias Kober, Tom Hilbert, Gian Franco Piredda
BACKGROUND AND PURPOSE: MS lesions exhibit varying degrees of axonal and myelin damage. A comprehensive description of lesion phenotypes could contribute to an improved radiologic evaluation of smoldering inflammation and remyelination processes. This stud ...
Amer Soc Neuroradiology2024Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing
Kessler et al. identify aberrant DNA recognition by cGAS/STING and IFN-I production by inflammatory macrophages as a driver of severe ANCA-associated vasculitis. Pharmacological interventions blocking this pathway ameliorate disease and accelerate recovery ...
ROCKEFELLER UNIV PRESS2022Valproic acid enhances recombinant mRNA and protein levels in transiently transfected Chinese hamster ovary cells
Florian Maria Wurm, David Hacker, Lucia Baldi Unser, Sarah Wulhfard
Valproic acid (VPA) is a small molecule that inhibits histone deacetylase activity. Here we report that VPA increases recombinant mRNA and protein levels in transiently transfected CHO DG44 cells. In the presence of VPA, transient recombinant antibody yiel ...
Elsevier2010Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor
Expression of surface immunoglobulin appears critical for the growth and survival of B-cell lymphomas. In follicular lymphoma, we found previously that the Ig variable (V) regions in the B-cell receptor express a strikingly high incidence of N-glycosylatio ...
American Society for Biochemistry and Molecular Biology2007Comparison between nucleation of pentacene monolayer islands on polymeric and inorganic substrates
Frank Nüesch, Libero Zuppiroli
We present a comparative study of the nucleation and growth of pentacene monolayer islands in the submonolayer regime onto inorganic substrates of SiO2 and sapphire (Al2O3) and organic substrates of poly(methyl-metacrylate) ...
2005Reduction of adenovirus E1A mRNA by RNAi results in enhanced recombinant protein expression in transiently transfected HEK293 cells
Florian Maria Wurm, David Hacker, Lucia Baldi Unser, Martin Bertschinger
Human embryonic kidney 293 (HEK293) cells, a widely used host for large-scale transient expression of recombinant proteins, are transformed with the adenovirus E1A and E1B genes. Because the E1A proteins function as transcriptional activators or repressors ...
2004Correlated growth in ultrathin pentacene films on silicon oxide: effect of deposition rate
Frank Nüesch, Libero Zuppiroli
Understanding the growth mechanism in molecular organic thin films is fundamental to their applications in organic electronics. We present an extensive study of the growth mechanism of pentacene thin films on silicon dioxide (SiO2) using atomic ...
APS through AIP2004Development of a bioprocess for murine dimeric IgA production
Monoclonal IgA was produced under serum free conditions by a murine hybridoma cell line (ZAC3) in a hollow fiber, a continuous stirred tank and a fluidized bed reactor. Differences in the antibody adsorption to DEAE chromatog. matrixes, an essential step i ...
1998Effects of culture conditions on the production and quality of monoclonal IgA
Urs von Stockar, Ian William Marison
Monoclonal IgA antibodies have been produced by a hybridoma cell line grown in different bioreactors using serum-contg. and protein-free media in both basal and fortified versions. The effects of culture conditions on IgA prodn. and quality were studied us ...
1997