Concept
Cytoskeleton
Related publications (200)
Stabilization of overlapping biofilaments by passive crosslinkers
The formation, maintenance and reorganization of the cytoskeletal filament network is essential for a number of cellular processes. While the crucial role played by active forces generated by motor proteins has been studied extensively, only recently the i ...
2018AFM contribution to unveil pro- and eukaryotic cell mechanical properties
Giovanni Dietler, Sandor Kasas, Petar Stupar
Atomic force microscopy is nowadays a well-established technique that permits the investigation of numerous parameters of living matter. In particular, it allows the exploration of the mechanical properties of living organisms in almost physiological condi ...
Elsevier20183D correlative electron microscopy reveals continuity of Brucella-containing vacuoles with the endoplasmic reticulum
Henning Paul-Julius Stahlberg, Shyan Huey Low
Entry of the facultative intracellular pathogen Brucella into host cells results in the formation of endosomal Brucella-containing vacuoles (eBCVs) that initially traffic along the endocytic pathway. eBCV acidification triggers the expression of a type IV ...
The Company of Biologists2018Podosomes, But not the Maturation status, Determine the Protease-Dependent 3D Migration in human Dendritic cells
Dendritic cells (DC) are professional Antigen-Presenting Cells scattered throughout antigen-exposed tissues and draining lymph nodes, and survey the body for pathogens. Their ability to migrate through tissues, a 3D environment, is essential for an effecti ...
2018A model for cellular mechanotransduction and contractility at finite strain
William Curtin, Mahmut Selman Sakar, Nikolaos Bouklas
In this work we introduce a theoretical and computational modeling framework for the contractile response of single cells triggered by external mechanical stimuli. The structural response due to the formation and dissociation of stress fibers is modeled fo ...
2018A model for cellular mechanotransduction and contractility at finite strain
William Curtin, Mahmut Selman Sakar, Nikolaos Bouklas
In this work we introduce a theoretical and computational modeling framework for the contractile response of single cells triggered by external mechanical stimuli. The structural response due to the formation and dissociation of stress fibers is modeled fo ...
2018Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape
Georg Fantner, John McKinney, Haig Alexander Eskandarian
In most well-studied rod-shaped bacteria, peptidoglycan is primarily crosslinked by penicillin-binding proteins (PBPs). However, in mycobacteria, crosslinks formed by L,D-transpeptidases (LDTs) are highly abundant. To elucidate the role of these unusual cr ...
ELIFE SCIENCES PUBLICATIONS LTD2018Probing the distribution of cortical components, including PtdIns(4,5)P2, during asymmetric division of C. elegans embryos
Asymmetric cell division is crucial for embryonic development and stem cell lineages. In the one-cell C. elegans embryo, a contractile cortical actomyosin network contributes to asymmetric division by segregating PAR proteins to discrete cortical domains. ...
EPFL2018Nonlinear microscopy for temporally and spatially resolved label-free imaging of living cells
The human brain consists of approximately a hundred billion of neurons that communicate through a unique series of biochemical and electrical processes. When neuronal networks are solicited, electrochemical processes happen involving millions of cells with ...
EPFL2018Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States
Hilal Lashuel, Mahmood Haj Yahya
The microtubule-associated protein Tau plays a central role in neurodegeneration and is a leading therapeutic target for the treatment of Alzheimer’s disease (AD). Several lines of evidence suggest that post-translational modifications (PTMs) regulate the ...
2018