Concept

Antiemetic

Related publications (4)

Natural compounds boldine and menthol are antagonists of human 5-HT

Background Impaired 5-HT3 receptor function is likely involved in the pathogenesis of functional gastrointestinal disorders (FGID) and 5-HT3 receptor antagonists are effective treatments for chemotherapy-induced nausea and vomiting (CINV) and irritable bow ...

2014

Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles

Paul Joseph Dyson, Angela Casini, Olivier Pierre Zava

The reaction of the five- or six-membered C,N or C,S-palladacycles [(L)PdCl]2 with PTA (1,3,5-triaza-7-phosphaadamantane) led to the monomeric complexes [(L)Pd(PTA)Cl] 6a, 6b and 7 where LH= N,N-dimethyl-1-phenylmethanamine, benzyl(methyl)sulfane or 1-meth ...

Royal Society of Chemistry2009

Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: a systematic study

Angela Casini

The antiproliferative properties of a group of 13 structurally diverse gold(III) compounds, including six mononuclear gold(III) complexes, five dinuclear oxo-bridged gold(III) complexes, and two organogold(III) compounds, toward several human tumor cell li ...

Springer-Verlag2009

Gold(III) compounds as anticancer agents: Relevance of gold-protein interactions for their mechanism of action

Paul Joseph Dyson, Christian Hartinger, Angela Casini

Gold(III) compds. constitute an emerging class of biol. active substances, of special interest as potential anticancer agents. During the past decade a no. of structurally diverse gold(III) complexes were reported to be acceptably stable under physiol.-lik ...

2008

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