In artificial intelligence, artificial immune systems (AIS) are a class of computationally intelligent, rule-based machine learning systems inspired by the principles and processes of the vertebrate immune system. The algorithms are typically modeled after the immune system's characteristics of learning and memory for use in problem-solving. The field of artificial immune systems (AIS) is concerned with abstracting the structure and function of the immune system to computational systems, and investigating the application of these systems towards solving computational problems from mathematics, engineering, and information technology. AIS is a sub-field of biologically inspired computing, and natural computation, with interests in machine learning and belonging to the broader field of artificial intelligence. Artificial immune systems (AIS) are adaptive systems, inspired by theoretical immunology and observed immune functions, principles and models, which are applied to problem solving. AIS is distinct from computational immunology and theoretical biology that are concerned with simulating immunology using computational and mathematical models towards better understanding the immune system, although such models initiated the field of AIS and continue to provide a fertile ground for inspiration. Finally, the field of AIS is not concerned with the investigation of the immune system as a substrate for computation, unlike other fields such as DNA computing. AIS emerged in the mid-1980s with articles authored by Farmer, Packard and Perelson (1986) and Bersini and Varela (1990) on immune networks. However, it was only in the mid-1990s that AIS became a field in its own right. Forrest et al. (on negative selection) and Kephart et al. published their first papers on AIS in 1994, and Dasgupta conducted extensive studies on Negative Selection Algorithms. Hunt and Cooke started the works on Immune Network models in 1995; Timmis and Neal continued this work and made some improvements.

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