Concept
Hyperlipidemia
Related publications (58)
Proteomics reveals unique plasma signatures in constitutional thinness
Loïc Dayon, Jörg Hager, Nele Gheldof
Purpose Studying the plasma proteome of control versus constitutionally thin (CT) individuals, exposed to overfeeding, may give insights into weight-gain management, providing relevant information to the clinical entity of weight-gain resistant CT, and dis ...
WILEY-V C H VERLAG GMBH2022Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice
Jonathan Paz Montoya, Marc Moniatte
Most cells acquire cholesterol by endocytosis of circulating low-density lipoproteins (LDLs). After cholesteryl ester de-esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms. Our previous work sug ...
2019Hypericin can cross barriers in the chicken's chorioallantoic membrane model when delivered in low-density lipoproteins
Georges Wagnières, Veronika Huntosova
Background: Low-density lipoproteins (LDL) were used as a natural drug delivery system for the transport of hypericin (Hyp) in the bloodstream of the chicken's chorioallantoic membrane model (CAM). Hyp was chosen as a model for hydrophobic drug used in pho ...
ELSEVIER SCIENCE BV2018The Sirt1 activator SRT3025 provides atheroprotection in Apoe(-/-) mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
Johan Auwerx, Kristina Schoonjans, Matthias Alexander Sokrates Stein, Tasneem Arsiwala
The deacetylase sirtuin 1 (Sirt1) exerts beneficial effects on lipid metabolism, but its roles in plasma LDL-cholesterol regulation and atherosclerosis are controversial. Thus, we applied the pharmacological Sirt1 activator SRT3025 in a mouse model of athe ...
Oxford University Press2015Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury
Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Younouss Faye
IntroductionAngiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin angiotensin system, which breaks down angiotensin II and forms angiotensin-(1-7). In erectile tissues, it has been documented that angiotensin II contributes to the development ...
Wiley-Blackwell2015Consequences of Exchanging Carbohydrates for Proteins in the Cholesterol Metabolism of Mice Fed a High-fat Diet
Sylviane Métairon, Martin Kussmann, Mireille Moser
Consumption of low-carbohydrate, high-protein, high-fat diets lead to rapid weight loss but the cardioprotective effects of these diets have been questioned. We examined the impact of high-protein and high-fat diets on cholesterol metabolism by comparing t ...
Public Library of Science2012Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration
Melody Swartz, Joseph Rutkowski, Sai Reddy
Lymphatic vessels are essential for lipid absorption and transport. Despite increasing numbers of observations linking lymphatic vessels and lipids, little research has been devoted to address how dysregulation of lipid balance in the blood, ie, dyslipidem ...
American Society for Investigative Pathology2009Collection of blood and plasma from the mouse
There are many elements in plasma that can act as surrogate markers of the physiological well-being of a mouse, thus making the collection of blood and plasma a general technique with many applications in mouse phenotyping. For example, the presence of cer ...
Wiley2006Lipid and bile acid analysis
Lipids are important body constituents that are vital for cellular, tissue, and whole-body homeostasis. Lipids serve as crucial membrane components, constitute the body's main energy reservoir, and are important signaling molecules. As a consequence of the ...
Wiley2006Mathematical and numerical models for transfer of low-density lipoproteins through the arterial walls: A new methodology for the model set up with applications to the study of disturbed lumenal flow
Alfio Quarteroni, Paolo Zunino
In this work we introduce and discuss several mathematical models, based on partial differential equations, devised to study the coupled transport of macromolecules as low-density lipoproteins in the blood stream and in the arterial walls. These models are ...
2005