Concept
Transitional epithelium
Related publications (36)
Identification of genes required for host-cell adhesion and antibiotic persistence of uropathogenic Escherichia coli via high-content screening
Uropathogenic Escherichia coli (UPEC) are the most common bacterial pathogens causing urinary tract infections (UTIs). Driven by the development of antibiotic resistant UPEC strains, UTIs have become a major public health issue and generate substantial hea ...
EPFL2022Microtissue models for studying the dynamics of host-pathogen interactions in the urinary bladder
Urinary tract infections (UTIs) are amongst the most common bacterial infections and are the second-most frequent reason for antibiotic prescriptions. Moreover, in about 25% of all treated cases, recurrence of infection occurs. Uropathogenic Escherichia co ...
EPFL2021Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection
John McKinney, Neeraj Dhar, Vivek Vijay Thacker, François Signorino-Gelo, Kunal Sharma, Thomas Marie Simonet
Uropathogenic Escherichia coli (UPEC) proliferate within superficial bladder umbrella cells to form intracellular bacterial communities (IBCs) during early stages of urinary tract infections. However, the dynamic responses of IBCs to host stresses and anti ...
2021Tubular Compressed Collagen Scaffolds for Ureteral Tissue Engineering in a Flow Bioreactor System
Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, Elif Vardar, Kalitha Pinnagoda, Mouti Elodie Mouloungui
Ureteral replacement by tissue engineering might become necessary following tissue loss after excessive ureteral trauma, after retroperitoneal cancer, or even after failed reconstructive surgery. This need has driven innovation in the design of novel scaff ...
Mary Ann Liebert, Inc2015Clonal, Self-Renewing and Differentiating Human and Porcine Urothelial Cells, a Novel Stem Cell Population
Yann Barrandon, Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, François Gorostidi
Although urothelial progenitor-like cells have been described in the human urinary tract, the existence of stem cells remains to be proven. Using a culture system that favors clonogenic epithelial cell growth, we evaluated and characterized clonal human ur ...
Public Library of Science2014Culture and Characterization of Human and Porcine Urothelial Progenitor Cells
An estimated 400 million people worldwide suffer from bladder diseases. However, little is known at the cellular level as to what causes or initiates many of these diseases. Therefore, this thesis has focused on understanding one cell type within the bladd ...
EPFL2012Engineered insulin-like growth factor-1 for improved smooth muscle regeneration
Peter Frey, Jeffrey Alan Hubbell, Kristen Lorentz, Lirong Yang
Insulin-like growth factor-1 (IGF-1) has been shown to induce potent mitogenic responses in various cell types, yet its sustained local delivery is still an underdeveloped domain in the clinic. We report here an engineered IGF-1 that facilitates extended l ...
2012Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut
Bruno Lemaitre, Sveta Chakrabarti
Typically, immune responses control the pathogen, while repair and stress pathways limit damage caused by pathogenesis. The relative contribution of damage to the outcome of pathogenesis and the mechanistic links between the immune and repair pathways are ...
Cell Press2012Loss of Cutaneous TSLP-Dependent Immune Responses Skews the Balance of Inflammation from Tumor Protective to Tumor Promoting
Freddy Radtke, Ute Koch, Craig Nowell, Matteo Di Piazza
Inflammation can promote or inhibit cancer progression. In this study we have addressed the role of the proinflammatory cytokine thymic stromal lymphopoietin (TSLP) during skin carcinogenesis. Using conditional loss- and gain-of-function mouse models for N ...
Elsevier2012Combination of metallomics and proteomics to study the effects of the metallodrug RAPTA-T on human cancer cells
Paul Joseph Dyson, Michael Groessl
An approach to characterize the interactions of RAPTA-T, a novel ruthenium-based anticancer drug candidate with intriguing antimetastatic properties, with human ovarian cancer cells in vitro is described. The distribution profile of the metallodrug within ...
Royal Society of Chemistry2012