Concept

Resting metabolic rate

Related publications (62)

Methods for increasing cellular energy expenditure

The present invention is directed to methods of treating a human for a variety of conditions by administering an agonist of the G protein coupled receptor TGR5. In addition, the invention includes methods for determining whether a test compound is likely t ...

2008

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure

Johan Auwerx, Kristina Schoonjans, Chikage Mataki

The role of the tumor suppressor retinoblastoma protein (pRb) has been firmly established in the control of cell cycle, apoptosis, and differentiation. Recently, it was demonstrated that lack of pRb promotes a switch from white to brown adipocyte different ...

National Academy of Sciences2007

Sirtuins: the 'magnificent seven', function, metabolism and longevity

Johan Auwerx, Kristina Schoonjans

The sirtuin family of histone deacetylases (HDACs) was named after their homology to the Saccharomyces cerevisiae gene silent information regulator 2 (Sir2). In the yeast, Sir2 has been shown to mediate the effects of calorie restriction on the extension o ...

2007

Evaluation of energy homeostasis

Johan Auwerx

Body mass and composition reflect the combined effects of three processes: energy intake, energy partitioning (storage), and energy expenditure. Energy is released from food as it is combusted to carbon dioxide and water, and is expended as heat and work w ...

Wiley2006

Microclimatic factors influencing refugium suitability for Rhodnius prolixus

Thierry Jean Heger

Rehydration in the triatomine bug Rhodnius prolixus (Stal) is dependent on the blood meal, and water balance regulation is crucial for survival of starving bugs. In an experimental arena with zones at different climatic conditions, starved R. prolixus nymp ...

2006

To act or not to act. Neural correlates of executive control of learned motor behavior

Friedhelm Christoph Hummel

Successful behavior requires contextual modulation of learned "programs", that is, the retrieval or nonretrieval (inhibition) of behavioral elements depending on situative context. Here we report neural correlates of these elementary aspects of behavior as ...

Elsevier2004

SRC-1 and TIF2 control energy balance between white and brown adipose tissues

Johan Auwerx

We have explored the effects of two members of the p160 coregulator family on energy homeostasis. TIF2-/- mice are protected against obesity and display enhanced adaptive thermogenesis, whereas SRC-1-/- mice are prone to obesity due to reduced energy expen ...

2003

Monitoring of temperature effects on animal cell metabolism in a packed bed process

Urs von Stockar, Ian William Marison

Animal cell (Chinese Hamster Ovary) concn. was detd. online in a packed bed process using dielec. spectroscopy. This enabled the evaluation of the effect of temp. on specific metabolic rates during 3 mo of continuous culture. The effect of low cultivation ...

2002

A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures

Urs von Stockar, Ian William Marison

Oxygen is a key substrate in animal cell metab. and its consumption is thus a parameter of great interest for bioprocess monitoring and control. A system for measuring it based on an oxygen balance on the liq. phase was developed. The use of a gas-permeabl ...

2000

Indirect biomass determination in case of non-constant metabolic rates

Urs von Stockar, Ian William Marison, Martin Rhiel

A novel approach for indirect biomass detn. in case of non-const. specific metabolic rates is reported. Specific glucose consumption rate was detd. during a first calibration culture for both free suspended and immobilized cells. It was expressed as a line ...

1999

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