Concept
Doxepin
Related publications (10)
Using Negative Control Populations to Assess Unmeasured Confounding and Direct Effects
Sometimes treatment effects are absent in a subgroup of the population. For example, penicillin has no effect on severe symptoms in individuals infected by resistant Staphylococcus aureus, and codeine has no effect on pain in individuals with certain polym ...
Lippincott Williams & Wilkins2024Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit
Douglas Hanahan, Ksenya Shchors, Aristea Massaras
The associations of tricyclic antidepressants (TCAs) with reduced incidence of gliomas and elevated autophagy in glioma cells motivated investigation in mouse models of gliomagenesis. First, we established that imipramine, a TCA, increased autophagy and co ...
Elsevier2015Natural compounds boldine and menthol are antagonists of human 5-HT
Background Impaired 5-HT3 receptor function is likely involved in the pathogenesis of functional gastrointestinal disorders (FGID) and 5-HT3 receptor antagonists are effective treatments for chemotherapy-induced nausea and vomiting (CINV) and irritable bow ...
2014Deletion of CREB-Regulated Transcription Coactivator 1 Induces Pathological Aggression, Depression-Related Behaviors, and Neuroplasticity Genes Dysregulation in Mice
Jean-René Cardinaux, Christophe Mérinat
Background: Mood disorders are polygenic disorders in which the alteration of several susceptibility genes results in dysfunctional mood regulation. However, the molecular mechanisms underlying their transcriptional dysregulation are still unclear. The tra ...
Elsevier Science Inc2012Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa
A screen of a library of synthetic drugs and natural product extracts identified a botanical extract that modulates the processing of amyloid precursor protein (APP) in cultured cells to produce a lowered ratio of amyloid-beta peptide (1-42) (Aβ42) relativ ...
2012Poutres MilliNewton – tests de collage de billes
Thomas Maeder, Nathalie Sophie Adeline Serra
Le but du présent travail était la qualification du collage, en remplacement du brasage, des billes de centrage de force sur les poutres MilliNewton, ce qui a le potentiel d'en simplifier et fiabiliser la production. Les billes ont été collées (même sérigr ...
EPFL2009MilliNewton – dérive due aux étapes finales
Dérive de l'offset du signal de sortie des poutres MilliNewton (1ère version, avec variantes), assemblées sur embase sans électronique par brasure tendre sans plomb Sn96 (96.5% Sn + 3.5% Ag), lors de tests à long terme. Quarante poutres MilliNewton, versio ...
EPFL2007MilliNewton – dérive due aux contraintes dans la brasure
Dérive de l'offset du signal de sortie des poutres MilliNewton (1ère version, avec variantes), assemblées sur embase sans électronique par brasure tendre sans plomb Sn96 (96.5% Sn + 3.5% Ag), lors de tests à long terme. Quarante poutres MilliNewton, versio ...
EPFL2007Dynamics of the 5-HT3A serotonin receptor in living cells
The 5-HT3 serotonin receptor belongs to the cys-loop ligand-gated ion channel (LGIC) family. It is located in the central and peripheral nervous system and is implicated in certain pathologic situations. The 5-HT3 receptor is investigated here, as a typica ...
EPFL2006Characterization of a mouse serotonin 5-HT3 receptor purified from mammalian cells
Horst Vogel, Rudolf Hovius, Alain Bernard
A serotonin 5-HT3 receptor was functionally expressed to high levels and on a large scale in mammalian cells with the Semliki Forest virus system. Conditions were optimized to maximize detergent solubilization of the receptor, while preserving ligand bindi ...
1998