Concept
Doxépine
Publications associées (10)
Using Negative Control Populations to Assess Unmeasured Confounding and Direct Effects
Sometimes treatment effects are absent in a subgroup of the population. For example, penicillin has no effect on severe symptoms in individuals infected by resistant Staphylococcus aureus, and codeine has no effect on pain in individuals with certain polym ...
Lippincott Williams & Wilkins2024Natural compounds boldine and menthol are antagonists of human 5-HT
Background Impaired 5-HT3 receptor function is likely involved in the pathogenesis of functional gastrointestinal disorders (FGID) and 5-HT3 receptor antagonists are effective treatments for chemotherapy-induced nausea and vomiting (CINV) and irritable bow ...
2014Deletion of CREB-Regulated Transcription Coactivator 1 Induces Pathological Aggression, Depression-Related Behaviors, and Neuroplasticity Genes Dysregulation in Mice
Jean-René Cardinaux, Christophe Mérinat
Background: Mood disorders are polygenic disorders in which the alteration of several susceptibility genes results in dysfunctional mood regulation. However, the molecular mechanisms underlying their transcriptional dysregulation are still unclear. The tra ...
Elsevier Science Inc2012Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa
A screen of a library of synthetic drugs and natural product extracts identified a botanical extract that modulates the processing of amyloid precursor protein (APP) in cultured cells to produce a lowered ratio of amyloid-beta peptide (1-42) (Aβ42) relativ ...
2012MilliNewton – dérive due aux étapes finales
Dérive de l'offset du signal de sortie des poutres MilliNewton (1ère version, avec variantes), assemblées sur embase sans électronique par brasure tendre sans plomb Sn96 (96.5% Sn + 3.5% Ag), lors de tests à long terme. Quarante poutres MilliNewton, versio ...
EPFL2007