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Concept
Coupling reaction
Summary
In organic chemistry, a coupling reaction is a type of reaction in which two reactant molecules are bonded together. Such reactions often require the aid of a metal catalyst. In one important reaction type, a main group organometallic compound of the type R-M (where R = organic group, M = main group centre metal atom) reacts with an organic halide of the type R'-X with formation of a new carbon-carbon bond in the product R-R'. The most common type of coupling reaction is the cross coupling reaction.
Richard F. Heck, Ei-ichi Negishi, and Akira Suzuki were awarded the 2010 Nobel Prize in Chemistry for developing palladium-catalyzed cross coupling reactions.
Broadly speaking, two types of coupling reactions are recognized:
Homocouplings joining two identical partners. The product is symmetrical
Heterocouplings joining two different partners. These reactions are also called cross-coupling reactions. The product is unsymmetrical, .
Coupling reactions are illustrated by the Ullmann reaction:
Cross-coupling reaction
Coupling reactions are routinely employed in the preparation of pharmaceuticals. Conjugated polymers are prepared using this technology as well.
Official source
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