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Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor, which controls adipocyte differentiation. We targeted with homologous recombination the PPAR gamma 2-specific exon B, resulting in a white adipose tissue knockdown of PPAR ...
One of the biggest difficulties for founders of new ventures is to raise capital for their entrepreneurial endeavors. Based on a discussion of several models of firm development, this paper analyses the financing requirements of young growth companies and ...
The development of new therapeutic approaches that aim to help the body exert its natural mechanisms for vascularized tissue growth (therapeutic angiogenesis) has become one of the most active areas of tissue engineering. Through basic research, several gr ...
We propose a method for brain atlas deformation in presence of large space-occupying tumors, based on an a priori model of lesion growth that assumes radial expansion of the lesion from its starting point. First, an affine registration brings the atlas and ...
During puberty and pregnancy, the breast undergoes major restructuring in order to produce a structure that can secrete and eject copious amounts of milk. By analogy to other branched organs such as the lung or the salivary gland, a large increase in surfa ...
Linear time-invariant (LTI) modeling is a powerful and simple tool to describe biomedical systems dynamics around given working points for a limited time horizon. However, when a larger range of behaviors is considered, and/or the time horizon becomes wide ...
Using transient expression, high amounts (>20 mg/mL) of secreted anti-human Rhesus-D IgG1 were produced in a suspension-adapted HEK293 EBNA cell line (Meissner et al., Biotechnol Bioeng 75: 197-203, 2001). Time of harvest was 3 days after transfection. For ...
In-situ reflectivity measurements of the growth surface during deposition in a Hydride Vapor Phase Epitaxy system are presented. The GaN growth rate increases linearly with the HCl flow and increases monotonically with the ammonia flow. Following the repla ...
A review. The classical method of metabolic engineering, identifying a rate-detg. step in a pathway and alleviating the bottleneck by enzyme overexpression, has motivated much research but has enjoyed only limited practical success. Intervention of other l ...
Encapsulation of the protein drug hGH in degradable polyethylene glycol-based hydrogel microspheres was demonstrated to result in burst-free release appropriate for a once-per-week prepn. of the drug. Small needle sizes, lack of burst, and lack of local in ...
