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Concept
Cell junction
Summary
Cell junctions or junctional complexes, are a class of cellular structures consisting of multiprotein complexes that provide contact or adhesion between neighboring cells or between a cell and the extracellular matrix in animals. They also maintain the paracellular barrier of epithelia and control paracellular transport. Cell junctions are especially abundant in epithelial tissues. Combined with cell adhesion molecules and extracellular matrix, cell junctions help hold animal cells together.
Cell junctions are also especially important in enabling communication between neighboring cells via specialized protein complexes called communicating (gap) junctions. Cell junctions are also important in reducing stress placed upon cells.
In plants, similar communication channels are known as plasmodesmata, and in fungi they are called septal pores.
In vertebrates, there are three major types of cell junction:
Adherens junctions, desmosomes and hemidesmosomes (anchoring junctions)
Gap junctions (communicating junction)
Tight junctions (occluding junctions)
Invertebrates have several other types of specific junctions, for example septate junctions or the C. elegans apical junction. In multicellular plants, the structural functions of cell junctions are instead provided for by cell walls. The analogues of communicative cell junctions in plants are called plasmodesmata.
Cells within tissues and organs must be anchored to one another and attached to components of the extracellular matrix. Cells have developed several types of junctional complexes to serve these functions, and in each case, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells as well as to proteins in the extracellular matrix.
Three types of anchoring junctions are observed, and differ from one another in the cytoskeletal protein anchor as well as the transmembrane linker protein that extends through the membrane:
Anchoring-type junctions not only hold cells together but provide tissues with structural cohesion.
Official source
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Ontological neighbourhood
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