Concept

Animal testing

Related publications (177)

Incorporation of Clathrochelate-Based Metalloligands in Metal-Organic Frameworks by Solvent-Assisted Ligand Exchange

Rosario Scopelliti, Kay Severin, Farzaneh Fadaei Tirani, Pascal Alexander Schouwink, Ophélie Marie Planes, José Luis Bila

Iron(II) cage complexes with terminal 4-pyridyl groups can be incorporated in metal-organic frameworks (MOFs) via solvent-assisted ligand exchange (SALE). Paddle -wheeled MOFs with N,N'-di-4-pyridylnaphthalenete-tracarboxydiimide pillars were used as start ...

AMER CHEMICAL SOC2020

Site-Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases

Hilal Lashuel, Luciano Andres Abriata, Jonathan Jean-Pierre Ricci, Anass Chiki, Andreas Reif, Driss Boudeffa

Post-translational modifications (PTMs) within the first 17 amino acids (Nt17) of exon 1 of the Huntingtin protein (Httex1) play important roles in modulating its cellular properties and functions in health and disease. In particular, phosphorylation of th ...

2020

FELASA accreditation of education and training courses in laboratory animal science according to the Directive 2010/63/EU

Marcel Gyger

This document describes how the Federation of European Laboratory Animal Science Associations (FELASA) accreditation addresses both the Directive 2010/63/EU and the related European Commission guidance document. The four EU Functions and beyond: FELASA acc ...

2019

Zebrafish: Housing and husbandry recommendations

This article provides recommendations for the care of laboratory zebrafish (Danio rerio) as part of the further implementation of Annex A to the European Convention on the protection of vertebrate animals used for experimental and other scientific purposes ...

2019

A fish intestinal barrier model to assess the interaction with chemicals in vitro

Hannah Inka Schug

The intestinal epithelium acts as vital gate keeper between the fish and its surrounding environment. A single layer of connected epithelial cells forms a selective barrier, which, among other essential functions, is important for nutrient uptake and defen ...

EPFL2019

Innovative Tools and in vivo Methods for Tuberculosis Drug Discovery and Development

Raphael Christopher Sommer

Worldwide, tuberculosis (TB) is the leading cause of death due to a single infectious agent, claiming 1.6 million human lives and causing >10 million new cases in 2017 alone, mostly in low-income regions. The intracellular pathogen Mycobacterium tuberculos ...

EPFL2019

A novel biomechanical approach for animal behaviour recognition using accelerometers

Kamiar Aminian, Pritish Chakravarty

Data from animal-borne inertial sensors are widely used to investigate several aspects of an animal's life, such as energy expenditure, daily activity patterns and behaviour. Accelerometer data used in conjunction with machine learning algorithms have b ...

2019

Rapid evaluation of bioactive Ti-based surfaces using an in vitro titration method

Paul Bowen, Jacques Lemaître, Weitian Zhao

The prediction of implant behavior in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. Simulated body fluids (SBFs) have been proposed and widely used to evaluate the bone-bonding ability of implant materia ...

Springer2019

Impact of Mineralogical Composition on Geotechnical Properties of Opalinus Clay

Lyesse Laloui, Alessio Ferrari, Eleonora Crisci

Opalinus Clay is the selected host geomaterial for the construction of underground geological disposals for radioactive waste in Switzerland. The formation has been studied in several sites, i.e. the Mont Terri laboratory, and several boreholes in the nort ...

2019

Dielectrophoresis‐assisted creation of cell aggregates under flow conditions using planar electrodes

Philippe Renaud, Harald Van Lintel, Jonathan Bastien Cottet, Soufian Lasli

We present a microfluidic platform allowing dielectrophoresis-assisted formation of cell aggregates of controlled size and composition under flow conditions. When specific ex- perimental conditions are met, negative dielectrophoresis allows efficient conce ...

2019

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