Concept

Mannich reaction

Related publications (78)

Formic Acid Dehydrogenation Catalysed by Tris(TPPTS) Ruthenium Species: Mechanism of the Initial "Fast" Cycle

Gabor Laurenczy, Andrew Francis Dalebrook, Arnaud Thevenon, Ewan Patrick Frost-Pennington

Water-soluble ruthenium m-triphenylphosphinetrisulfonate (TPPTS) complexes are excellent catalysts for formic acid dehydrogenation. Interestingly, the choice of metal catalyst precursor has a direct influence on initial activities. The reaction with hexaaq ...

Wiley-V C H Verlag Gmbh2014

Contributions to the Chemistry of the Cyclopentadienyl Complex [Cp^RuCl2](2) ("Cp-roof" = eta(5)-1-Methoxy-2,4-tert-butyl-3-neopentylcyclopentadienyl)

Rosario Scopelliti, Kay Severin, Euro Solari, Barnali Dutta, Julie Risse

The dimeric ruthenium complex Cp^RuCl2 is easily accessible in a one-pot reaction from RuCl3(solv)(n) and tert-butylacetylene. It features sterically very demanding "Cp-roof" ligands (Cp^ = eta(5)-1-methoxy-2,4-tert-butyl-3-neopentylcyclopentadienyl), ...

Wiley-Blackwell2014

Three-Component Povarov Reaction–Heteroannulation with Arynes: Synthesis of 5,6-Dihydroindolo[1,2‑a]quinolines

Qian Wang, Jieping Zhu, Ala Bunescu

A reaction of 2-acyl substituted tetrahydroquinolines, prepared by Lewis acid-catalyzed three-component reaction of α-oxo aldehydes, anilines, and dienophiles, with in situ generated arynes afforded 5,6-dihydroindolo[1,2-a]- quinolines in good to excellent ...

Amer Chemical Soc2014

Synthesis of Saturated Heterocycles via Metal-Catalyzed Formal Cycloaddition Reactions That Generate a C–N or C–O Bond

Jérôme Waser

In this section, the synthesis of saturated N- and O-heterocycles via formal cycloaddition is presented. The main focus is on metal-catalyzed reactions involving C–C or C–X σ bond cleavage in three- or four-membered rings. After a fast presentation of pion ...

Springer Verlag2013

Catalytic Enantiospecific [3+2] Annulation of Aminocyclopropanes with Ketones

Jérôme Waser, Fides Benfatti, Florian Patrick Marie Daniel De la Barre De Nanteuil

The first enantiospecific [3+2] annulation of D-A amino-cyclopropanes with ketones is reported herein (see scheme; Phth = phthaloyl). The reaction is catalyzed by 5 mol % of tin(IV) chloride at -78 °C and gives aminotetra-hydrofurans bearing a C5-quaternar ...

2012

Ruthenium-Catalyzed Sequential Enyne Cross-Metathesis/ATRA Reactions

Kay Severin, Euro Solari, Gregor Kiefer, Jesus Ruiz

Sequential enyne cross-metathesis reactions of arylalkynes with ethylene followed by atom transfer radical addition (ATRA) with ethyl dichloroacetate or dichloroacetonitrile provide 1,5-dichloropent-2-ene derivatives. The second-generation Grubbs alkyliden ...

Wiley-Blackwell2012

Iron-Catalyzed [3+2] Annulation of Aminocyclopropanes with Aldehydes: Stereoselective Synthesis of Aminotetrahydrofurans

Jérôme Waser, Fides Benfatti, Florian Patrick Marie Daniel De la Barre De Nanteuil

The first method for the [3 + 2] annulation of donor acceptor aminocyclopropanes with aldehydes is reported. The reaction is catalyzed by iron trichlorlde on alumina in yields up to 99% and with excellent cis selectivities (up to >20:1) and represents a st ...

American Chemical Society2012

Kinetic Modeling of Batch Reaction Processes

Kinetic models have been demonstrated to be useful in on-line batch monitoring systems. The ability to monitor a reaction in real time is invaluable to the production process of industrial and pharmaceutical products. However, it is not a commonly used tec ...

2012

Connection of Metallamacrocycles via Dynamic Covalent Chemistry: A Versatile Method for the Synthesis of Molecular Cages

Rosario Scopelliti, Kay Severin, Clément Schouwey, Anton Granzhan

A modular approach for the synthesis of cage structures is described. Reactions of [(arene)RuCl2]2 [arene = p-cymene, 1,3,5-C6H3Me3, 1,3,5-C6H3(i-Pr)3] with formyl-substituted 3-hydroxy-2-pyridone ligands provide trinuclear metallamacrocycles with pendant ...

2011

Chiral Phosphoric Acid-Catalyzed Enantioselective Three-Component Povarov Reaction Using Enecarbamates as Dienophiles: Highly Diastereo- and Enantioselective Synthesis of Substituted 4-Aminotetrahydroquinolines

Jieping Zhu

A chiral phosphoric acid (5)-catalyzed three-component Povarov reaction of aldehydes 2, anilines 3, and enecarbamates 4 afforded cis-4-amino-2-aryl(alkyl)-1,2,3,4-tetrahydroquinolines 1 in high yields with excellent diastereoselectivities (>95%) and almost ...

2011

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