Concept
Lipid-lowering agent
Related publications (52)
Membrane specificity of the human cholesterol transfer protein STARD4
Charlotte Julie Caroline Gehin
STARD4 regulates cholesterol homeostasis by transferring cholesterol between the plasma membrane and endoplasmic reticulum. The STARD4 structure features a helix-grip fold surrounding a large hydrophobic cavity holding the sterol. Its access is controlled ...
Academic Press Ltd- Elsevier Science Ltd2024Plant sterols and cholesterol metabolism are associated with five-year cognitive decline in the elderly population
Christopher Clark, Mehdi Gholam
Dysregulations in cholesterol metabolism are associated with neurodegenerative and vascular pathologies, and dementia. Diet-derived plant sterols (phytosterols) have cholesterol-lowering, anti-inflammatory, and antioxidant properties and may interfere with ...
CELL PRESS2023KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage
The Krüppel-associated box zinc finger protein (KRAB-ZFP) family diversified in mammals. The majority of human KRAB-ZFPs bind transposable elements (TEs), however, since most TEs are inactive in humans it is unclear whether KRAB-ZFPs emerged to suppress TE ...
2020Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated a pancreatic cancer patient-derived organoid (PDO) library that recapitul ...
2018Cholesteryl ester transfer between lipoproteins does not require a ternary tunnel complex with CETP
The cholesteryl ester transfer protein (CETP) enables the transfer of cholesteryl ester (CE) from high density lipoproteins (HDL) to low-density lipoproteins (LDL) in the plasma compartment. CETP inhibition raises plasma levels of HDL cholesterol; a ternar ...
Elsevier BV2016Inflammatory and metabolic responses to high-fat meals with and without dairy products in men
Postprandial inflammation is an important factor for human health since chronic low-grade inflammation is associated with chronic diseases. Dairy products have a weak but significant anti-inflammatory effect on postprandial inflammation. The objective of t ...
Cambridge University Press2015The Sirt1 activator SRT3025 provides atheroprotection in Apoe(-/-) mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
Johan Auwerx, Kristina Schoonjans, Matthias Alexander Sokrates Stein, Tasneem Arsiwala
The deacetylase sirtuin 1 (Sirt1) exerts beneficial effects on lipid metabolism, but its roles in plasma LDL-cholesterol regulation and atherosclerosis are controversial. Thus, we applied the pharmacological Sirt1 activator SRT3025 in a mouse model of athe ...
Oxford University Press2015Treatment with KLEPTOSE (R) CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response
The ability of pharmacological agents to target both "classical" risk factors and inflammation may be key for successful outcomes in the prevention and treatment of atherogenesis. Among the promising drugs interfering with cholesterol metabolism, we invest ...
Elsevier Science Inc2015GentleRain: Cheap and Scalable Causal Consistency with Physical Clocks
Willy Zwaenepoel, Calin Iorgulescu, Jiaqing Du, Amitabha Roy
GentleRain is a new causally consistent geo-replicated data store that provides throughput comparable to eventual consistency and superior to current implementations of causal consistency. GentleRain uses a periodic aggregation protocol to deter- mine whet ...
ACM2014Bulk Fermi surface and electronic properties of Cu0.07Bi2Se3
The electronic properties of Cu0.07Bi2Se3 have been investigated using Shubnikov-de Haas and optical reflectance measurements. Quantum oscillations reveal a bulk, three-dimensional Fermi surface with anisotropy k(F)(c)/k(F)(ab) approximate to 2 and a modes ...
Amer Physical Soc2013