Concept
Glycerophospholipid
Related publications (36)
Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction
Johan Auwerx, Olivier Burri, Xiaoxu Li, Tanes Imamura de Lima, Giacomo Vincenzo Giorgio Von Alvensleben, Martin Rainer Wohlwend, Pirkka-Pekka Untamo Laurila, Ludger Jan Elzuë Goeminne, Barbara Moreira Crisol, Amélia Lalou, Renata Mangione
Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis pathway in the pathogenesis ...
2023Imaging Cu2+ binding to charged phospholipid membranes by high-throughput second harmonic wide-field microscopy
Sylvie Roke, David Roesel, Seonwoo Lee
The interaction of divalent copper ions (Cu2+) with cell membranes is crucial for a variety of physiological processes of cells, such as hormone synthesis and cellular energy production. These interactions would not be possible without membrane hydration. ...
AIP Publishing2021Brain NAD Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans
Rolf Gruetter, Lijing Xin, Özlem Ipek, Maya Shevlyakova
The brain requires a large amount of energy, mostly derived from the metabolism of glucose, which decreases substantially with age and neurological diseases. While mounting evidence in model organisms illustrates the central role of brain nicotinamide aden ...
FRONTIERS MEDIA SA2020Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities
Milena Maria Schuhmacher, Pavel Barahtjan
Every cell produces thousands of distinct lipid species, but insight into how lipid chemical diversity contributes to biological signaling is lacking, particularly because of a scarcity of methods for quantitatively studying lipid function in living cells. ...
2020Metabolic rescue of muscle and muscle stem cells in muscle disease
Duchenne muscular dystrophy (DMD), caused by the mutation of dystrophin gene, is an X-linked disorder that affects 1 in 3500 males, leading to progressive muscle degeneration and eventually resulting in premature death. Increasing evidence indicates that D ...
EPFL2020Chemistry of Lipid Membranes from Models to Living Systems: A Perspective of Hydration, Surface Potential, Curvature, Confinement and Heterogeneity
Sylvie Roke, Orly Bagunu Tarun, Halil Ibrahim Okur
Lipid membranes provide diverse and essential functions in our cells relating to transport, energy harvesting and signaling. This variety of functions is controlled by the molecular architecture, such as the presence of hydrating water, specific chemical c ...
2019A Click Cage: Organelle‐Specific Uncaging of Lipid Messengers
Lipid messengers exert their function on short time scales at distinct subcellular locations, yet most experimental approaches for perturbing their levels trigger cell-wide concentration changes. Herein, we report on a coumarin-based photocaging group that ...
2018Lipid exchange and signaling at ER–Golgi contact sites
Meticulous observations of the cell perinuclear region where the Golgi and the endoplasmic reticulum (ER) networks intermingle have revealed close contact sites of barely 20 nm between these two organelles. Recent studies demonstrate that molecular machine ...
2018Sphingolipid metabolic flow controls phosphoinositide turnover at the trans ‐Golgi network
Giovanni D'Angelo, Howard Riezman, Riccardo Rizzo
Sphingolipids are membrane lipids globally required for eukaryotic life. The sphingolipid content varies among endomembranes with pre- and post-Golgi compartments being poor and rich in sphingolipids, respectively. Due to this different sphingolipid conten ...
2017Interfacial Structure and Hydration of 3D Lipid Monolayers in Aqueous Solution
Sylvie Roke, Nikolay Smolentsev, Yixing Chen, Halil Ibrahim Okur, Evangelia Zdrali
Three-dimensional (3D) phospholipid monolayers at hydrophobic surfaces are ubiquitous and found in nature as adiposome organelles or in man-made materials such as drug delivery systems. However, the molecular level understanding of such monolayers remains ...
American Chemical Society2017