Protein aggregation

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Neurodegenerative disease

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Related lectures (32)

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Mitochondrial Protein Import: Challenges and Mechanisms

Delves into challenges and mechanisms of mitochondrial protein import, focusing on precursor accumulation and protein folding.

Bacterial AAA+ Protease: Activity Control and Toxic Deregulation

Explores the activity control and toxic deregulation of a bacterial AAA+ protease, focusing on the role of AAA+ machines in protein quality control.

SOD1 Pathology: Mechanisms and Implications

Explores SOD1 mutations in ALS, focusing on toxic gain of function, protein misfolding, and non-cell autonomous disease.

Cryo-EM and Parkinson's Disease

Delves into Cryo-EM's role in studying Parkinson's Disease and protein structures at the nano-level.

Hsp70 Chaperone Binding: Substrate Selectivity and Function

Explores the selective promiscuity in binding of the E. coli Hsp70 chaperone to unfolded or misfolded protein substrates, examining its implications in protein folding mechanisms.

Self-attraction of DNA: Mediated Interactions

Discusses the self-attraction of DNA and its mediated interactions.

Molecular Mechanism of Chaperonin GroEL

Explores the molecular mechanism and client preference of chaperonin GroEL in protein folding and aggregation prevention.

RNA Metabolism: ALS Genetics

Delves into RNA metabolism in ALS genetics, focusing on key proteins, mutations, and implications in neurodegeneration.

Protein Structure and Function: Folding and Degradation

Covers protein folding, maturation, degradation, and the implications of misfolding in neurodegenerative diseases.

Polymer Structure and Biological Relevance

Covers the molecular structure of polymers, the transcription process, and the implications of protein misfolding in diseases.