Concept

Protein aggregation

Related publications (213)

ERAD substrates: Which way out?

Global folding of polypeptides entering the endoplasmic reticulum ( ER) starts as soon as they emerge from the narrow Sec61 translocon. Attainment of the native structure can take from several minutes to hours, depending on the gene product. Until then, no ...

2010

Probing Mechanism and Transition State of RNA Refolding

Philipp Wenter

Kinetics and the atomic detail of RNA refolding are only poorly understood. It has been proposed that conformations with transient base pairing interaction are populated during RNA refolding, but a detailed description of those states is lacking. By NMR an ...

2010

Structure and function of the molecular chaperone Hsp104 from yeast

Hilal Lashuel

The molecular chaperone Hsp104 plays a central role in the clearance of aggregates after heat shock and the propagation of yeast prions. Hsp104's disaggregation activity and prion propagation have been linked to its ability to resolubilize or remodel prote ...

Wiley-Blackwell2009

Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses

Tristan Bolmont

Molecular probes for selective Identification of protein aggregates are important to advance our understanding of the molecular pathogenesis underlying cerebral amyloidoses. Here we report the chemical design of pentameric thiophene derivatives, denoted lu ...

American Chemical Society2009

Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions

Patrick Aebischer

We explored the relationship between ubiquitin proteasome system (UPS) and lysosomal markers and the formation of alpha-synuclein (alpha-syn) inclusions in nigral neurons in Parkinson disease (PD). Lysosome Associated Membrane Protein 1(LAMP1), Cathepsin D ...

2009

Induction of cerebral beta-amyloidosis: Intracerebral versus systemic A beta inoculation

Tristan Bolmont

Despite the importance of the aberrant polymerization of A beta in the early pathogenic cascade of Alzheimer's disease, little is known about the induction of A beta aggregation in vivo. Here we show that induction of cerebral beta-amyloidosis can be achie ...

National Academy of Sciences2009

Selective cross-linking of interacting proteins using self-labeling tags

Kai Johnsson, Grazvydas Lukinavicius, Kui Thong Tan

We have designed molecules that permit the selective cross-linking (S-CROSS) of interacting proteins in cell lysates and the sensitive detection of the trapped complexes through in-gel fluorescence scanning. S-CROSS requires the expression of the putative ...

American Chemical Society2009

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

Michaël Unser, Patrick Aebischer, Bernard Schneider, Daniel Sage, Samareh Azeredo da Silveira Lajaunias

Phosphorylation is involved in numerous neurodegenerative diseases. In particular, alpha-synuclein is extensively phosphorylated in aggregates in patients suffering from synucleinopathies. However, the share of this modification in the events that lead to ...

Oxford University Press2009

Influence of Structural Variation on the Anticancer Activity of RAPTA-Type Complexes: ptn versus pta

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Anna Katherine Renfrew, Andrew Douglas Phillips

[M(η6-arene)(ptn)Cl]X (M = Ru, Os; arene = p-cymene, benzene, toluene, hexamethylbenzene; ptn = 3,7-dimethyl-7-phospha-1,3,5-triazabicyclo[3.3.1]nonane; X = Cl-, BF4-) were prepd. and characterized spectroscopically. X-ray diffraction was addnl. used to ch ...

2009

Local conformational dynamics in alpha-helices measured by fast triplet transfer

Beat Fierz

Coupling fast triplet-triplet energy transfer (TTET) between xanthone and naphthylalanine to the helix-coil equilibrium in alanine-based peptides allowed the observation of local equilibrium fluctuations in alpha-helices on the nanoseconds to microseconds ...

2009

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