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Kui Thong Tan

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Related publications (4)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

Evaluating Cellular Drug Uptake with Fluorescent Sensor Proteins

Kai Johnsson, Rudolf Hovius, Rudolf Griss, Kui Thong Tan, Silvia Scarabelli

We are introducing a new approach to evaluate cellular uptake of drugs and drug candidates into living cells. The approach is based on converting the protein target of a given class of compounds into a fluorescent biosensor. By measuring the binding of dif ...

Amer Chemical Soc2017

A Semisynthetic Fluorescent Sensor Protein for Glutamate

Kai Johnsson, Luc Reymond, Rudolf Griss, Matthias Albert Brun, Kui Thong Tan

We report the semisynthesis of a fluorescent glutamate sensor protein on cell surfaces. Sensor excitation at 547 nm yields a glutamate-dependent emission spectrum between 550 and 700 nm that can be exploited for ratiometric sensing. On cells, the sensor di ...

2012

Semisynthesis of fluorescent metabolite sensors on cell surfaces

Horst Vogel, Kai Johnsson, Luc Reymond, Rudolf Griss, Joachim Piguet, Matthias Albert Brun, Kui Thong Tan, Ruud Peters

Progress in understanding signal transduction and metabolic pathways is hampered by a shortage of suitable sensors for tracking metabolites, second messengers, and neurotransmitters in living cells. Here we introduce a class of rationally designed semisynt ...

2011