Concept

Protein aggregation

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Protein aggregation

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Molecular chaperones inject energy from ATP hydrolysis into the non-equilibrium stabilisation of native proteins

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species

Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models

Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of beta-amyloid-42 aggregation

Experimental Milestones in the Discovery of Molecular Chaperones as Polypeptide Unfolding Enzymes

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

Structure of Crenezumab Complex with A beta Shows Loss of beta-Hairpin

A subcutaneous cellular implant for passive immunization against amyloid-beta reduces brain amyloid and tau pathologies

Nanoscale studies link amyloid maturity with polyglutamine diseases onset