Concept
Enantiomeric excess
Related publications (39)
Near-Enantiopure Trimerization of 9-Ethynylphenanthrene on a Chiral Metal Surface
Harald Brune, Roland Widmer, Aliaksandr Yakutovich, Jan Prinz, Samuel Thomas Stolz
Enantioselectivity in heterogeneous catalysis strongly depends on the chirality transfer between catalyst surface and all reactants, intermediates, and the product along the reaction pathway. Herein we report the first enantioselective on-surface synthesis ...
2020Exploiting the chirality of intermetallic PdGa
The intermetallic compound PdGa has recently attracted considerable interest for combining high catalytic activity with high reaction selectivity in symmetric heterogeneous catalysis, in particular semi-hydrogenation of acetylene and methanol steam reformi ...
EPFL2020Iridium-catalyzed acid-assisted asymmetric hydrogenation of oximes to hydroxylamines
Asymmetric hydrogenations are among the most practical methods for the synthesis of chiral building blocks at industrial scale. The selective reduction of an oxime to the corresponding chiral hydroxylamine derivative remains a challenging variant because o ...
AMER ASSOC ADVANCEMENT SCIENCE2020Chiral Cyclopentadienyl Ligands: Design, Syntheses, and Applications in Asymmetric Catalysis
Nicolai Cramer, Benoît Daniel Bertrand Audic
The creation of new chiral ligands capable of providing high stereocontrol in metal-catalyzed reactions is crucial in modern organic synthesis. The production of bioactive molecules as single enantiomers is increasingly required, and asymmetric catalysis w ...
WILEY-V C H VERLAG GMBH2020Catalytic Enantioselective Transformations with Chiral Cyclopentadienyl Ruthenium(II) Complexes
The chemistry of cyclopentadienyl ruthenium(II) complexes plays an important role in ruthenium catalysis because of its high potential for various transformations. However, asymmetric catalysis with chiral cyclopentadienyl ruthenium(II) complexes is still ...
EPFL2020Development of Catalytic Asymmetric C-H Functionalizations with Chiral Cyclopentadienyl Iridium(III) Complexes
Cp*Ir(III) catalyzed C-H functionalization is a growing field, since it provides novel complementary reactivities, but enantioselective C-H functionalization reactions with this metal remain a niche. This thesis investigates CpXIr(III) catalyzed asymmetric ...
EPFL2019Synthesis, Properties, and Two-Dimensional Adsorption Characteristics of 5-Amino[6]hexahelicene
A convergent synthesis of racemic 5-amino[6]hexahelicene is described. Cross-coupling reactions are used to assemble a pentacyclic framework, and a metal-catalyzed ring-closure comprises the final step. The enantiomers were separated by means of chromatogr ...
Wiley-Blackwell2016Phosphoric Acid Catalyzed Diastereo- and Enantioselective Synthesis of Substituted 1,3-Diaminotetralins
The reaction of anilines and phenylacetaldehydes in the presence of chiral phosphoric acid afforded optically active 1,2-trans, 2,3-cis 1,3-diaminotetralins in high yields with excellent diastereo- and enantioselectivities. The trans/cis product was readil ...
Amer Chemical Soc2014Ruthenium(II) arene PTA (RAPTA) complexes: impact of enantiomerically pure arene ligands
Paul Joseph Dyson, Catherine Marie Amélie Clavel, Kelly Joan Kilpin, Shona Cammack
Organometallic ruthenium(II) arene complexes containing the PTA ligand ([Ru(eta(6)-arene)Cl-2(PTA)], PTA = 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1] decane, termed RAPTA) show pharmacologically relevant antitumour properties in vitro. Two new enantiomeric p ...
Royal Society of Chemistry2013Lack of Enantioselectivity in the SULT1A3-catalyzed Sulfoconjugation of Normetanephrine Enantiomers: An In Vitro and Computational Study
Sandrine Gerber, Jean-Baptiste Gualtierotti
(1R)-Normetanephrine is the natural stereoisomeric substrate for sulfotransferase 1A3 (SULT1A3)-catalyzed sulfonation. Nothing appears known on the enantioselectivity of the reaction despite its potential significance in the metabolism of adrenergic amines ...
Wiley-Blackwell2013