Concept

Upper motor neuron

Related publications (233)

Gradients of structure-function tethering across neocortex

The white matter architecture of the brain imparts a distinct signature on neuronal coactivation patterns. Interregional projections promote synchrony among distant neuronal populations, giving rise to richly patterned functional networks. A variety of sta ...

PNAS2019

Brain-spine interface technologies to alleviate gait deficits after Parkinson's disease

Flavio Raschella

Gait and balance deficits are motor disabilities that typically develop late in the progression of Parkinson's disease (PD). These deficits are thought to be the result of dysregulated neural activity in the cortico-basal ganglia-thalamic-cortical motor lo ...

EPFL2019

Regional T-1 mapping of the whole cervical spinal cord using an optimized MP2RAGE sequence

Tobias Kober

While T1 measurements present multiple challenges (robustness, acquisition time), the recently proposed MP2RAGE sequence (magnetization-prepared two rapid acquisition gradient echoes) has opened new perspectives to characterize tissue microstructure change ...

WILEY2019

Whole brain measurements of the positive BOLD response variability during a finger tapping task at 7 T show regional differences in its profiles

Wietske Van der Zwaag, Yohan Boillat

PURPOSE: The positive BOLD response can vary across brain regions. Here, the positive BOLD responses of motor regions, including the cerebellum, were investigated by fast fMRI acquisition. METHODS: The participants were asked to perform an event-related fi ...

2019

Dopaminergic modulation of motor network compensatory mechanisms in Parkinson's disease

Michael Herzog, Bogdan Draganski, Maya Anna Jastrzebowska, Renaud Marquis

The dopaminergic system has a unique gating function in the initiation and execution of movements. When the interhemispheric imbalance of dopamine inherent to the healthy brain is disrupted, as in Parkinson's disease (PD), compensatory mechanisms act to st ...

2019

Altered interplay between endoplasmic reticulum and mitochondria in Charcot-Marie-Tooth type 2A neuropathy

Bernard Schneider, Roman Chrast, Catherine Maclachlan, Nathalie Marie Géraldine Bernard, Cylia Cloé Rochat, Omar El Mansour, Manisha Juneja

Mutations in the MFN2 gene encoding Mitofusin 2 lead to the development of Charcot-Marie-Tooth type 2A (CMT2A), a dominant axonal form of peripheral neuropathy. Mitofusin 2 is localized at both the outer membrane of mitochondria and the endoplasmic reticul ...

NATL ACAD SCIENCES2019

Combined rehabilitation promotes recovery of motor functionality in a mouse model of stroke

Silvestro Micera, Maria Pasquini

Neuro-rehabilitative research is developing novel strategies to enhance the effectiveness of therapies after stroke by using a combination of physical and plasticizing treatments 1-3. Previous studies have shown that repeated optogenetics stimulation of ne ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Hand perceptions induced by single pulse transcranial magnetic stimulation over the primary motor cortex

Olaf Blanke, Andrea Serino, Michela Bassolino, Matteo Franza, Matteo Vissani, Giuliana Sorrentino

Background When single pulse transcranial magnetic stimulation (TMS) is applied over the primary motor cortex (M1) with sufficient intensity, it evokes muscular contractions (motor-evoked potentials, MEPs) and muscle twitches (TMS-evoked movements). Partic ...

2019

Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

Jean-Philippe Thiran, Graham Knott, Maxime Descoteaux, Giorgio Innocenti, Tim Bjørn Dyrby

The axonal composition of cortical projections originating in premotor, supplementary motor (SMA), primary motor (a4), somatosensory and parietal areas and descending towards the brain stem and spinal cord was characterized in the monkey with histological ...

OXFORD UNIV PRESS INC2019

Prefrontal-Premotor Pathways and Motor Output in Well-Recovered Stroke Patients

Friedhelm Christoph Hummel

Structural brain imaging has continuously furthered our knowledge how different pathways of the human motor system contribute to residual motor output in stroke patients. Tract-related microstructure of pathways between primary and premotor areas has been ...

2019

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