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I did not use WeChat as my main method or main source of materials, but I realized that during my fieldwork in China, I did use WeChat very often to help me collect data, and I see the potential of using WeChat as an increasingly important method for furth ...
Cyclic peptides are ring-shaped molecules that emerged as a promising class of therapeutics. While it is often difficult to find small molecule binders for challenging disease targets, cyclic peptides can bind to featureless surfaces or inhibit protein-pro ...
Protein-protein interactions (PPIs) play important roles in many diseases and their modulation is an attractive strategy for developing new therapeutics. However, the relatively large and often flat binding surfaces of PPIs makes the development of inhibit ...
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How not to get lost in the quest to publish an Open Access article? This game focuses on how a researcher can make their publication compliant with the Open Access requirements of their institution and funders. To be compliant today, a researcher should tr ...
Efficient use of energy is essential for today's supercomputing systems, as energy cost is generally a major component of their operational cost. Research into "green computing" is needed to reduce the environmental impact of running these systems. As such ...
This article explains how the Replica project is a particular case of different professionals coming together to achieve the digitization of a historical photographic archive, intersecting complementary knowledge specific to normally unconnected communitie ...
In his seminal work, Halbwachs (1950: 132–139) already noted a homology between the resistance of stone and the resistance of cities’ inhabitants to being displaced or effaced. This contribution seeks to study the relationship between the built environment ...
Macrocycles are an attractive class of molecules due to their good binding properties and yet rather small size that allows, in many cases, crossing membranes to reach intracellular targets. In comparison to classical small molecule drugs, macrocycles are ...
The application of digital technologies to historical newspapers has changed the research landscape historians were used to. An Eldorado? Despite undeniable advantages, the new digital affordance of historical newspapers also transforms research practices ...
Thiol groups are suitable handles for site-selectively modifying, immobilizing or cyclizing individual peptides or entire peptide libraries. A limiting step in producing the thiol-functionalized peptides is the chromatographic purification, which is partic ...