Publications related to Antigen

Microchannel-guided capture antibody patterning on beads for multiple protein detection arrays

Martinus Gijs, Hüseyin Cumhur Tekin, Venkataragavalu Sivagnanam, Sébastien Vaneberg

We present the rapid fabrication of custom protein micro-arrays, in less than 35 minutes, on the surface of immobilized beads using microchannel-guided flows driven by a single syringe pump. The commercially available beads provide robust micro-array surfa ...

2011

Comparative genomics of Esx genes from clinical isolates of Mycobacterium tuberculosis provides evidence for gene conversion and epitope variation

Stewart Cole, Jacques Rougemont, Swapna Uplekar

The 23-membered Esx protein family is involved in the host-pathogen interactions of Mycobacterium tuberculosis. These secreted proteins are among the most immunodominant antigens recognized by the human immune system and have thus been used to develop vacc ...

2011

The neural correlates of the shine-through effect

Michael Herzog, Gijs Plomp, Yvonne Evelina Thunell

Shine-through occurs when a briefly presented vernier stimulus is followed by a grating consisting of 25 lines: the vernier appears brighter, longer, wider, and superimposed on the grating. However, vernier offset discrimination is strongly impeded if two ...

2011

Nanoparticles for immunotherapy

Eleonora Simeoni, Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil, Sai Reddy

Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. ...

2010

Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation

Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Iraklis Kourtis

Vaccines aiming to activate cytotoxic T cells require cross-presentation of exogenous antigen by antigen-presenting cells (APCs). We recently developed a synthetic nanoparticle vaccine platform that targets lymph node-resident dendritic cells (DCs), capabl ...

Elsevier2010

Role of lymphatic vessels in tumor immunity: passive conduits or active participants?

Melody Swartz, Amanda Waite Lund

Research in lymphatic biology and cancer immunology may soon intersect as emerging evidence implicates the lymphatics in the progression of chronic inflammation and autoimmunity as well as in tumor metastasis and immune escape. Like the blood vasculature, ...

Springer Verlag2010

Synthesis of Pyridyl Disulfide-Functionalized Nanoparticles for Conjugating Thiol-Containing Small Molecules, Peptides, and Proteins

Jeffrey Alan Hubbell, Conlin O'Neil, Urara Hasegawa

Previously we reported emulsion polymerization of propylene sulfide with Pluronic F127 as an emulsifier, yielding nanoparticles (NPs) in the 25 nm size range. Immunologically functional NPs were prepared by adding an antigen Pluronic conjugate to the polym ...

2010

Transmural flow modulates cell and fluid transport functions of lymphatic endothelium

Melody Swartz, Witold Waldemar Kilarski, Joseph Rutkowski, James Brandon Dixon, Dimana Miteva

RATIONALE: Lymphatic transport of peripheral interstitial fluid and dendritic cells (DCs) is important for both adaptive immunity and maintenance of tolerance to self-antigens. Lymphatic drainage can change rapidly and dramatically on tissue injury or infl ...

American Heart Association2010

Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function

Pedro Romero, Olivier Michielin, Nathalie Rufer

Protective adaptive immune responses rely on TCR-mediated recognition of Ag-derived peptides presented by self-MHC molecules. However, self-Ag (tumor)-specific TCRs are often of too low affinity to achieve best functionality. To precisely assess the relati ...

2010

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Antigen

Microchannel-guided capture antibody patterning on beads for multiple protein detection arrays

Comparative genomics of Esx genes from clinical isolates of Mycobacterium tuberculosis provides evidence for gene conversion and epitope variation

To B or not to B: B cells and the Th2-type immune response to helminths

The neural correlates of the shine-through effect

Nanoparticles for immunotherapy

Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation

Role of lymphatic vessels in tumor immunity: passive conduits or active participants?

Synthesis of Pyridyl Disulfide-Functionalized Nanoparticles for Conjugating Thiol-Containing Small Molecules, Peptides, and Proteins

Transmural flow modulates cell and fluid transport functions of lymphatic endothelium

Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function

Graph Chatbot

Chat with Graph Search

Microchannel-guided capture antibody patterning on beads for multiple protein detection arrays

Comparative genomics of Esx genes from clinical isolates of Mycobacterium tuberculosis provides evidence for gene conversion and epitope variation

Role of lymphatic vessels in tumor immunity: passive conduits or active participants?

To B or not to B: B cells and the Th2-type immune response to helminths

Nanoparticles for immunotherapy

Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation

Synthesis of Pyridyl Disulfide-Functionalized Nanoparticles for Conjugating Thiol-Containing Small Molecules, Peptides, and Proteins

Transmural flow modulates cell and fluid transport functions of lymphatic endothelium

The neural correlates of the shine-through effect

Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function