Venkataragavalu Sivagnanam

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Exploring Living Multicellular Organisms, Organs, and Tissues Using Microfluidic Systems

Martinus Gijs, Venkataragavalu Sivagnanam

American Chemical Society2013

Chaotic mixing using source-sink microfluidic flows in a PDMS chip

Ata Tuna Ciftlik, Martinus Gijs, Abdeljalil Sayah, Venkataragavalu Sivagnanam, Hüseyin Cumhur Tekin, Caroline Vandevyver

We present an active fixed-volume mixer based on the creation of multiple source–sink microfluidic flows in a polydimethylsiloxane (PDMS) chip without the need of external or internal pumps. To do so, four different pressure-controlled actuation chambers are arranged on top of the 5 μl volume of the mixing chamber. After the mixing volume is sealed/fixed by microfluidic valves made using ‘microplumbing technology’, a virtual source–sink pair is created by pressurizing one of the membranes and, at the same time, releasing the pressure of a neighboring one. The pressurized air deforms the thin membrane between the mixing and control chambers and creates microfluidic flows from the squeezed region (source) to the released region (sink) where the PDMS membrane is turned into the initial state. Several schemes of operation of virtual source–sink pairs are studied. In the optimized protocol, mixing is realized in just a sub-second time interval, thanks to the implementation of chaotic advection.

Springer-Verlag2011

High-Performance Protein Preconcentrator Using Microchannel-Integrated Nafion Strip

Martinus Gijs, Meng Shen, Venkataragavalu Sivagnanam, Hui Yang

A microfluidic device for protein preconcentration based on the electrokinetic trapping principle is proposed. It comprises a Nafion strip which is simply cut from a commercially available membrane and integrated into a polydimethylsiloxane (PDMS) microfluidic structure using a guiding channel. By applying low voltage (1000 of fluorescently labeled bovine serum albumin (BSA) within a few minutes. Moreover, a numerical study of the preconcentration effect is presented to microscopically understand the phenomenon in our type of device.

IEEE2011